Ọgwụgwọ na-emegide ihe
Ọgwụgwọ antisense bụ ụdị ọgwụgwọ nke na-eji oligonucleotides antisense (ASOs) lekwasị anya na ihe a na akpọ ozi RNA (mRNA). ASOs nwere ike ịgbanwe ngosipụta mR[1] site na usoro dịgasị iche iche, gụnyere ribonuclease H na-emebi pre-mRNA, mgbochi steric kpọmkwem, na mmetuta nke imeghari ma ọ bụ ịchịkwa ihe n'ihe nke ọdịnaya exon site na njikọ ebe na pre-m RNA. A kwadoro ọtụtụ ASOs na mba United States, European Union, na ebe ndị ọzọ.
- ↑ (June 2007) "Achieving targeted and quantifiable alteration of mRNA splicing with Morpholino oligos". Biochemical and Biophysical Research Communications 358 (2): 521–7. DOI:10.1016/j.bbrc.2007.04.172. PMID 17493584.