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Adenosarcoma

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Adenosarcoma (nke a na-akpọkwa Müllerian adenosarcoma) bụ akpụ na-adịghị ahụkebe nke na-eme n'ahụ ụmụ nwaanyị nọ n'afọ ndụ niile, mana ọ na-abụkarị mgbe ha nwụsịrị ịhụ nsọ. Adenosarcoma na-esite n'anụ ahụ mesenchymal ma nwee ngwakọta nke ihe ndị dị na akpụ nke adenoma, akpụ nke sitere na epithelial, na sakoma, akpụ sitere na anụ ahụ njikọ.[1][2] Adenoma, ma ọ bụ akụkụ epithelial nke akpụ ahụ, adịghị njọ, ebe sarcomatous stroma bụ ihe ọjọọ.[3] Ebe a na-ahụkarị nke adenosarcoma bụ akpa nwa, mana ọ pụkwara ime na sevis na ovaries. Ọ na-esikarị ike na akụkụ ahụ nwaanyị na ọwa falopian yana ebe pelvic ma ọ bụ peritoneal, dị ka omentum, karịsịa na ndị nwere akụkọ ihe mere eme nke endometriosis.[3][4] Ọnọdụ ndị a na-adịghị ahụkebe nke adenosarcoma n'èzí akụkụ ahụ nwanyị na-emekarị n'ime imeju, afọ, [4] akụrụ, [4] yana eriri afọ [4] ma na-ejikọkarị na endometriosis. [4][4]:references" typeof="mw:Extension/ref">[./Adenosarcoma#cite_note-fifth-5 [5]][5][6][7][8]

Müllerian adenosarcoma na ntofey sarcomatous bụ ụdị adenosarcome siri ike nke a na-ahụ site na ịwa ahụ na metastases ọbụna mgbe a chọpụtara ya na mbido.[9] A na-achọpụta oke uto nke sarcomatous mgbe akụkụ sarcomatoos nke adenosarcoma mejupụtara ihe karịrị nke akpụ ahụ.[3] Adenosarcomas anaghị enwekarị metastases dị anya, mana ha nwere ọchịchọ maka ịlọghachi mpaghara.[2][10][11]

Adenosarcoma ke akpa nwa

[dezie | dezie ebe o si]

pesenti iri abụọ na ise Uterine adenosarcoma bụ ụdịdị nke uterine sarcomas. Uterine sarcomas na-akpata atọ ruo pesenti itoolu nke ọrịa kansa akpa nwa, na ise ọma ise ruo pesenti itoolu nke uterine sarcomas bụ adenosarcomas.[5] Ihe mgbaàmà a na-ahụkarị bụ ọbara ọgbụgba n'ahụ nwanyị. Mgbaàmà ndị ọzọ gụnyere ihe mgbu pelvic, ibu afọ, ma ọ bụ nsị nke akụkụ ahụ nwanyị.[12] Uterine adenosarcoma na-esikarị na endometrium.[1]

Uterine adenosarcomas nwere ihe kachasị na perimenopausal na postmenopausal ụmụ nwanyị na-eto eto nke dị afọ 50, mana ụfọdụ n'ime ụmụaka. Ịdị ndụ ka mma ma e jiri ya tụnyere ụdị sarcomas akpa nwa ndị ọzọ. Ọdịnihu nke uterine adenosarcoma na-adabere na ọkwa na ma ọ bụrụ na uto sarcomatous gabigara ókè dị.[13]

Ihe Ndị Na-eme Ihe Ize ndụ

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E nweghị kpomkwem ihe kpatara adenosarcoma. Ihe ize ndụ ndị nwere ike ịgụnye akụkọ ahụike nke endometriosis na ojiji nke estrogen modulating agents dị ka tamoxifen. Ihe ndị ọzọ nwere ike ịbụ ihe ize ndụ gụnyere radiation pelvic gara aga na ogologo oge estrogen exposure[5][14]

Nlekọta a na-ahụkarị bụ hysterectomy zuru oke nke afọ na salpingo-oophorectomy. A naghị emekarị Lymphadenectomy n'ihi na ọ na-adịkarịghị na lymph node metastasis. E nweghị ọgwụgwọ ọgwụ, Ọgwụgwọ hormone, ma ọ bụ ọgwụgwọ radiation. [5] [15][16] N'ihi ụkọ nke adenosarcoma, enwere data pere mpe iji duzie mkpebi ọgwụgwọ, ọkachasị n'ihe gbasara akpụ na-aga n'ihu ma ọ bụ na-agbasa.[3] Enwere ike ịtụle ọgwụgwọ ọgwụ na ndị ọrịa nwere ọganihu ma ọ bụ akpụ na-enweghị ike iwepụ kpamkpam site na ịwa ahụ. A tụwo aro na adenosarcomas nke akpa nwa nwere ike imeghachi omume na doxorubicin / ifosfamide na gemcitabine / documentaxel chemotherapy.[17] Ojiji nke ọgwụgwọ hormone na ọrịa na-aga n'ihu ma ọ bụ na-agbasa agbasa na-ejedebe na akụkọ ikpe.[3][16]

  1. ↑ 1.0 1.1 NCI Dictionary of Cancer Terms: Adenosarcoma." National Cancer Institute, National Institutes of Health, www.cancer.gov/publications/dictionaries/cancer-terms/def/adenosarcoma.
  2. ↑ Carroll, A., Ramirez, P. T., Westin, S. N., Soliman, P. T., Munsell, M. F., Nick, A. M., ... & Fleming, N. D. (2014). Uterine adenosarcoma: an analysis on management, outcomes, and risk factors for recurrence. Gynecologic oncology, 135(3), 455-461.
  3. ↑ 3.0 3.1 Podduturi, V., & Pinto, K. R. (2016, January). Mullerian adenosarcoma of the cervix with heterologous elements and sarcomatous overgrowth. In Baylor University Medical Center Proceedings (Vol. 29, No. 1, pp. 65-67). Taylor & Francis.
  4. ↑ 4.0 4.1 Mullerian Adenosarcoma of the Female Genital Tract. McCluggage, W. Glenn MD [Review] Advances in Anatomic Pathology. 17(2):122-129, March 2010.
  5. ↑ 5.0 5.1 5.2 5.3 Nathenson, M. J., Ravi, V., Fleming, N., Wang, W. L., & Conley, A. (2016). Uterine adenosarcoma: a review. Current oncology reports, 18(11), 68.
  6. ↑ Vara AR, Ruzics EP, Moussabeck O, Martin DC. Endometrioid adenosarcoma of the bladder arising from endometriosis. J Urol. 1990;143(4):813–5.
  7. ↑ Sameshima N, Marutsuka K, Tsukino H, Kamoto T, Kono S, Asada Y. So-called 'adenosarcoma' of the kidney a novel adult renal tumor with a cystic appearance. Pathol Int. 2011;61(5):313–8.
  8. ↑ Kondi-Pafiti A, Spanidou-Carvouni H, Papadias K, Hatzistamou-Kiari I, Kontogianni K, Liapis A, et al. Malignant neoplasms arising in endometriosis: clinicopathological study of 14 cases. Clin Exp Obstet Gynecol. 2004;31(4):302–4.
  9. ↑ Patrelli, T. S., Gizzo, S., Di Gangi, S., Guidi, G., Rondinelli, M., & Nardelli, G. B. (2011). Cervical Mullerian adenosarcoma with heterologous sarcomatous overgrowth: a fourth case and review of literature. BMC cancer, 11(1), 236.
  10. ↑ Clement PB, Scully RE. Mullerian adenosarcoma of the uterus: a clinicopathologic analysis of 100 cases with a review of the literature. Hum Pathol. 1990;21(4):363–381
  11. ↑ Verschraegen CF, Vasuratna A, Edwards C, Freedman R, Kudelka AP, Tornos C, Kavanagh JJ. Clinicopathologic analysis of mullerian adenosarcoma: the M.D. Anderson Cancer Center experience. Oncol Rep. 1998;5(4):939–944
  12. ↑ McCluggage, Glenn W. "Uterine Adenosarcoma." Uterine Adenosarcoma, Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland, 2009, uscapknowledgehub.org/site~/98th/pdf/companion12h05.pdf.
  13. ↑ Andre Pinto and Brooke Howitt (2016) Uterine Adenosarcoma. Archives of Pathology & Laboratory Medicine: March 2016, Vol. 140, No. 3, pp. 286-290.
  14. ↑ Stern RC, Dash R, Bentley RC, Snyder MJ, Haney AF, Robboy SJ. Malignancy in endometriosis: frequency and comparison of ovarian and extraovarian types. Int J Gynecol Pathol. 2001;20(2):133–9.
  15. ↑ Özen Ö. Müllerian adenosarcoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/uterusadenosarcoma.html. Accessed March 20th, 2019
  16. ↑ 16.0 16.1 Nathenson, M. J., Conley, A. P., Lin, H., Fleming, N., & Ravi, V. (2017). Treatment of recurrent or metastatic uterine adenosarcoma. Sarcoma, 2017.
  17. ↑ M. J. Nathenson, V. Ravi, N. Fleming, W.-L. Wang, and A. Conley, "Uterine adenosarcoma: a review," Current Oncology Reports, vol. 18, no. 11, p. 68, 2016.
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