Alan Christoffels

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Alan Christoffels
Mmádu
ụdịekerenwoke Dezie

Alan Christoffels bụ onye sayensị bioinformatics, agụmakwụkwọ, na onye edemede. [1] bụ Prọfesọ nke Bioinformatics, na onye nduzi nke South African National Bioinformatics Institute na Mahadum nke Western Cape. [2] na-eje ozi dị ka onye ndụmọdụ dị elu na Africa Centres for Disease Control and Prevention Pathogen genomics & Partnerships na DSI / NRF Research Chair na Bioinformatics na Public Health Genomics.

Ọrụ nchọpụta Christoffels [3] na mpaghara mmekọrịta onye na-ebute ọrịa, evolushọn mkpụrụ ndụ ihe nketa, pathogen genomics, na Biobank LIMS.

Christoffels bụ onye guzobere Global Emerging Pathogens Consortium, [4] onye a họpụtara ka ọ bụrụ onye otu Academy of Science of South Africa, [5] na onye isi oche nke African Society for Bioinformatics and Computational Biology site na 2020 ruo 2022. [6] họpụtara ya dị ka onye otu Royal Society of South Africa na 2022.

Mmụta[dezie | dezie ebe o si]

Christoffels gụsịrị akwụkwọ na BSc. na Microbiology na Biochemistry na 1992 na BSc (Hons.) na Pharmacology site na Mahadum Cape Town na 1993. N'agbata afọ 1995 na 1997, ọ debara aha ya na Mahadum Stellenbosch maka MSc. na Genetics.[7] Nnyocha hiwere isi na nchọpụta nke akara ọhụrụ na eserese dị mma nke ọrịa obi na-efe n'ógbè (PFHB1). [1] Ọ gara n'ihu na Ph.D. na bioinformatics na South African National Bioinformatics Institute University of the Western Cape. Isiokwu edemede bụ, "Ọgbọ nke akara mkpụrụ ndụ ihe nketa mmadụ na itinye ya n'ọrụ na ọrịa". [1]

Ọrụ[dezie | dezie ebe o si]

Christoffels malitere ọrụ agụmakwụkwọ ya na 1994 dị ka onye na-ahụ maka Genetics na Biochemistry na Mahadum Stellenbosch. N'agbata afọ 2001 na afọ 2004, o nwere postdoctoral fellowship na Institute of Molecular & Cell Biology na Singapore. N'ịbụ onye nhọpụta a sochiri, ọ rụrụ ọrụ dị ka onye enyemaka Prọfesọ na Mahadum Nkà na ụzụ Nanyang nke dị na Singapore. Ka oge na-aga, ọ bụ osote prọfesọ site na 2007 ruo 2012 na South African National Bioinformatics Institute na Mahadum nke Western Cape . [8] [9] kwalitere ya n'ọkwa Prọfesọ n'afọ 2013 ma na-ejide nhọpụta a ugbu a.

Site na 2009, Christoffels na-eje ozi dị ka onye nduzi nke South African National Bioinformatics Institute na Mahadum nke Western Cape . [10] N'ime afọ ise sochirinụ, ọ rụrụ ọrụ na bọọdụ ndị nduzi maka International Society for Computational Biology (ISCB). Ọ nọ na-ejide nhọpụta nke SA Medical Research Council Unit Director na Bioinformatics Capacity Development Unit kemgbe afọ 2012. [11] oge na-aga, ọ rụrụ ọrụ dị mkpirikpi dị ka osote onye isi oche nke South African Society for Bioinformatics . [1] [12] họpụtara ya dị ka onye isi oche nke African Society of Bioinformatics & Computational Biology na 2020 maka afọ abụọ.

N'ịbụ nke nzukọ ndị metụtara ya nke Bill & Melinda Gates Foundation kpọrọ, Christoffels na ndị mmekọ mba ụwa malitere atụmatụ zuru ụwa ọnụ a na-akpọ Public Health Alliance for Genomic Epidemiology [13] n'ọnwa Ọktoba 2019 na nzukọ GrandChallenges na Ethiopia. Ọ na-eje ozi dị ka onye isi nchọpụta nke atụmatụ a. [14] na-ejikọta prototypes nyocha ndị e mepụtara na ụlọ nyocha ahụ n'ime ìgwè ndị ọrụ n'ime njikọ ahụ.

Nnyocha[dezie | dezie ebe o si]

Christoffels nwere ihe karịrị akwụkwọ 400 n'okpuru aha ya. [3] Nnyocha [15] na-agụnye mmekọrịta onye na-ebute ọrịa, pathogen genomics, evolushọn nke mkpụrụ ndụ ihe nketa na-elekwasị anya na nkọwa nke mkpụrụ ndụ na nyocha data usoro.

Bioinformatics nke ahụike ọha na eze[dezie | dezie ebe o si]

Christoffels [16] otu ndị ọkà mmụta sayensị na ụlọ nyocha ya nke dị na South African National Bioinformatics Institute gosipụtara usoro mbụ nke SARS-CoV-2, nje na-akpata COVID-19, nke a chọtara na South Africa. [17] [18] na-adịbeghị anya na-egosi na ọ na-eme nchọpụta banyere ịgbasa usoro nlekota ọrịa na kọntinent Afrịka.

Christoffels mepụtara teknụzụ maka itinye bioinformatics na ahụike ọha na eze. O mepụtara usoro nyocha maka data usoro ụkwara nta a na-akpọ COMBAT-TB. Enwere ike itinye ngwá ọrụ [19] na ntọala ndị a kpaara ókè.

Biobank LIMS[dezie | dezie ebe o si]

[20] na otu ndị nchọpụta, Christoffels mepụtara usoro njikwa maka biobanking, Laboratory Information Management System (LIMS) na South African National Bioinformatics Institute. Ebumnuche nke usoro njikwa bụ ịnakọta, chekwaa, nhazi na, jikwaa ihe nlele nke ọma. Usoro nchekwa ihe n[21] dị ndụ nke mmadụ a dabere na usoro njikwa ọdịnaya weebụ Plone.

Ihe na-ebute ọrịa[dezie | dezie ebe o si]

Christoffels lekwasịrị anya na nyocha nke genomics ya na nje na-ebute ọrịa. [22]'afọ 2016, ọ kọwara RNA na-abụghị koodu (miRNA) na Anopheles funestus, ma kwuo ọrụ nke obere mkpụrụ ndụ ihe nketa ndị a na nghọta nke njikwa parasitic site na anwụnta na-amị ọbara. O duziri ọrụ tsetse fly genome n'etiti afọ 2008 na 2014 ebe ya na ụmụ akwụkwọ ya mụrụ ụzọ nnụnụ si achịkwa usoro ahụike nke ya ma chebe onwe ya megide nsị iron. [23] mechara jiri usoro nyocha ya kọwaa usoro RNA na-abụghị koodu na Black soldier fly.

Usoro nke mkpụrụ ndụ ihe nketa na ọrụ nkọwa (2004-2016)[dezie | dezie ebe o si]

Nnyocha mbụ Christoffels lekwasịrị anya na nhazi, nkọwa, na nyocha nke genomes. Ọ nyochara nchịkọta nke mkpụrụ ndụ ihe nketa na nkọwa nke rubripes Fugu. Site na ihe karịrị 95% nke usoro, a na-egosi na 80% nke nzukọ ahụ dị na ọtụtụ scaffolds. Nnyocha ahụ kọrọ na na na genome, DNA na-emegharị ugboro ugboro na-ewe ihe na-erughị otu ụzọ n'ụzọ isii nke usoro ahụ, ebe loci nke mkpụrụ ndụ ihe nketa na-ewe otu ụzọ n"ụzọ atọ nke genome. O gosikwara na mmepe protein kemgbe 450 nde afọ, ọ bụ ezie na ụzọ atọ n'ụzọ anọ nke protein mmadụ nwere ma ọ bụ enweghị homologs pufferfish. [24]'inye usoro dị ịrịba ama nke mkpụrụ ndụ ihe nketa, njikọ echekwara n'etiti Fugu rubripes na ụmụ mmadụ na-egosi ichekwa nke akụkụ nke chromosomes jikọtara ya na nna nna ya. E mere ntụnyere dị n'etiti usoro usoro nke Fugu na ụmụ mmadụ maka ịchọpụta mpaghara chromosomal paralogous na Fugu. E gosipụtara mkpụrụ ndụ ihe nketa abụọ na Fugu mgbe ejiri nyocha phylogenetic nke Fugu, usoro mmadụ na nke na-enweghị azụ. Nnyocha ahụ gosipụtara ihe akaebe maka mkpụrụ ndụ ihe nketa 425 nke azụ na Fugu ma gosipụta na ọ dịkarịa ala 6.6% nke genome na-anọchite anya paralogons nke azụ. Nnyocha ahụ [25]-atụkwa aro n'ụzọ siri ike na duplication zuru oke n'oge mgbanwe azụ ray-finned, nke nwekwara ike ime tupu mmalite nke teleosts.

N'afọ 2013, Christoffels kọrọ nyocha nke African coelacanth genome. [26] Usoro nke mkpụrụ ndụ ihe nketa nyere mgbanwe mkpụrụ ndụ ihe okike nke [27]-ekwu maka mgbanwe site na gburugburu mmiri gaa n'ala. E mere nnyocha ahụ iji nweta nghọta banyere evolushọn tetrapod. Nnyocha phylogenomic gosipụtara njikọ dị nso nke azụ lungfish na tetrapod kama coelacanth. Mkpụrụ ndụ ihe nketa protein nke Coelacanth kpughekwara ọganihu [28] nwayọ karịa nke tetrapod.

N'afọ 2013, Christoffels dechara nkọwa nke coelacanth genome na ụlọ nyocha ya. [29] oge na-aga, e mere nyocha na ndị na-anabata ihe na coelacanth ma gosipụta na ndekọ nke ndị na-anata ihe na-esi ísì ụtọ GPCR (CRs) nke Coelacanth na-akwado ọnọdụ ya dị n'etiti.

[30] Tsetse were ihe fọrọ nke nta [31] ọ bụrụ afọ iri. [32][33] [34] n'òtù ndị isi na-ahụ maka ọrụ ahụike, [1] ma duzie nyocha sayensị site n'ilekọta ụmụ akwụkwọ Ph.D. ndị nyochara mpaghara dị iche iche nke ahụike n'ụzọ zuru ezu dịka ọ metụtara nchedo ebumpụta ụwa megide pathogen (Trypanosome), [2] Trypanosomatid SNAREs ntụnyere, [35] mgbaàmà kemịkal ịchọta onye ọbịa, [36] na ụlọ nkwalite na Tsetse.

N'ịbụ onye ọrụ nhazi ya na coelacanth na Tsetse genomes sochiri, Christoffels duziri nzukọ nke genome na nkọwa nke Asian Seabass na 2014. [37] Ìgwè ahụ jikọtara maka ogologo oge mbụ (PacBio) na obere oge (illumina) usoro data iji jikọta mkpụrụ ndụ ihe nketa na-abụghị ihe nlereanya eukaryotic n'oge ahụ. [38] duziri ndị otu mgbakọ na nkọwa na South Africa na Singapore. [1] [39] kọwakwara parameters maka ihe ndị na-abụghị ihe nlereanya.

Mmekọrịta obodo[dezie | dezie ebe o si]

O dere akwụkwọ atọ, nke akpọrọ How to be a Health Activist: Teacher's Guide, How to Be a Health Activists: A Life Orientation Workbook, na How to Be an Health Activist, A life skills workbook for grades 7-9 learningers.

N'oge niile ọ na-eme nchọpụta, Christoffels agbakwunyere akụkụ nke itinye aka na obodo n'ọrụ ya. O nwetara nke a na mbụ site na itinye mmata banyere ụkwara nta n'ime ọrụ ọmụmụ ụlọ akwụkwọ. [40] mechara mepụta akwụkwọ ọdịyo maka ịkọrọ uru nke biobanks n'ọtụtụ asụsụ.

Onyinye na nsọpụrụ[dezie | dezie ebe o si]

  • 2014 - Onyinye ọlaọcha nke Kansụl Nnyocha Ahụike nke South Africa
  • 2015 - Hamilton Naki Award, National Research Foundation [41]
  • [42] - Fulbright Visiting Scholar Award [1]
  • 2017 - Onyinye Alumnus pụtara ìhè, Mahadum nke Western Cape

Akwụkwọ[dezie | dezie ebe o si]

Akwụkwọ[dezie | dezie ebe o si]

Isiokwu ndị a họọrọ[dezie | dezie ebe o si]

  • [Ihe e dere n'ala ala peeji] [Ihe e dere n'ala ala peeji] Nchịkọta nke ogbunigwe zuru oke na nyocha nke genome nke Fugu rubripes. [Ihe e dere n'ala ala peeji]
  • [Ihe e dere n'ala ala peeji] Nnyocha Fugu genome na-enye ihe akaebe maka duplication zuru oke n'oge mmalite nke azụ ray-finned. Molecular Biology and Evolution, 21 (6), 1146-1151.
  • [Ihe e dere n'ala ala peeji] [Ihe e dere n'ala ala peeji] African coelacanth genome na-enye nghọta banyere tetrapod evolution. [Ihe e dere n'ala ala peeji]
  • [Ihe e dere n'ala ala peeji] [Ihe e dere n'ala ala peeji] Nzukọ nke ọkwa Chromosomal nke Asian seabass genome site na iji usoro ogologo na-agụ na ọtụtụ akwa. PLoS genetics, 12 (4), e1005954.
  • [Ihe e dere n'ala ala peeji] Nchọpụta na njirimara nke microRNAs gosipụtara na African malaria vector Anopheles funestus ndụ stages site na iji usoro nhazi dị elu. [Ihe e dere n'ala ala peeji]
  • [Ihe e dere n'ala ala peeji] [Ihe e dere n'ala ala peeji] Nchịkọta nke mkpụrụ ndụ ihe nketa zuru oke maka nghọta ka mma banyere ọdịiche nke mkpụrụ ndụ nketa n'etiti ndị South Africa. Nkwurịta okwu okike, 8 (1), 1-12.
  • [Ihe e dere n'ala ala peeji] COMBAT-TB-NeoDB: ịkwalite nyocha ụkwara nta site na nyocha njikọta site na iji teknụzụ nchekwa data eserese. Bioinformatics, 36 (3), 982-983.
  • [Ihe e dere n'ala ala peeji] COMBAT-TB Workbench: Ime ka Mycobacterium dị ike nke ụkwara nta Bioinformatics dị mfe. [Ihe e dere n'ala ala peeji]

Edensibia[dezie | dezie ebe o si]

  1. ↑ Professor Alan Christoffels, Director SANBI, visits DELGEME. delgeme.org. Archived from the original on 2022-08-29. Retrieved on 2023-12-26.
  2. ↑ Prof. Alan Christoffels.
  3. ↑ 3.0 3.1 Alan Christoffels. scholar.google.com.
  4. ↑ Alan Christoffels, PhD « ICREID.
  5. ↑ Members – ASSAf.
  6. ↑ UWC Professor elected to the Royal Society of South Africa.
  7. ↑ Prof. Alan Christoffels. repository.uwc.ac.za.
  8. ↑ H3Africa Conference participant details1..
  9. ↑ Prof Alan Christoffels. Archived from the original on 2022-08-29. Retrieved on 2023-12-26.
  10. ↑ Prof. Alan Christoffels – Inter-University Institute for Data Intensive Astronomy (11 February 2019).
  11. ↑ SANBI Director, Prof Alan Christoffels appointed as a Senior Advisor at the Africa CDC. South African National Bioinformatics Institute.
  12. ↑ Africa. www.iscb.org.
  13. ↑ Public Health Alliance for Genomic Epidemiology.
  14. ↑ Prof Alan Christoffels – SANBI – South African National Bioinformatics Institute.
  15. ↑ Research Gate Profile.
  16. ↑ Spotlight (April 14, 2020). The Genetic Fingerprint: How scientists unlocked SA's SARS-CoV-2 virus. Daily Maverick.
  17. ↑ Tessema (October 1, 2020). "Accelerating genomics-based surveillance for COVID-19 response in Africa". The Lancet Microbe 1 (6): e227–e228. DOI:10.1016/S2666-5247(20)30117-8. PMID 32838350. 
  18. ↑ How genome sequencing helps in tackling COVID-19 variants -WHO (October 2, 2021).
  19. ↑ Van Heusden (2022). "The COMBAT-TB Workbench: Making Powerful Mycobacterium tuberculosis Bioinformatics Accessible". mSphere 7 (1): e0099121. DOI:10.1128/msphere.00991-21. PMID 35138128. 
  20. ↑ BAfrica. Archived from the original on 2021-11-28. Retrieved on 2023-12-26.
  21. ↑ Hiller (October 19, 2017). South Africa's Centre for Proteomic & Genomic Research (CPGR) to implement Baobab LIMS to boost lab quality control and operational performance. CPGR.
  22. ↑ Allam (November 8, 2016). "Identification and characterization of microRNAs expressed in the African malaria vector Anopheles funestus life stages using high throughput sequencing". Malaria Journal 15 (1): 542. DOI:10.1186/s12936-016-1591-0. PMID 27825380. 
  23. ↑ DeRaedt (March 17, 2022). "microRNA profile of Hermetia illucens (black soldier fly) and its implications on mass rearing". PLOS ONE 17 (3): e0265492. DOI:10.1371/journal.pone.0265492. PMID 35298540. 
  24. ↑ Aparicio (August 23, 2002). "Whole-Genome Shotgun Assembly and Analysis of the Genome of Fugu rubripes". Science 297 (5585): 1301–1310. DOI:10.1126/science.1072104. PMID 12142439. 
  25. ↑ Fugu Genome Analysis Provides Evidence for a Whole-Genome Duplication Early During the Evolution of Ray-Finned Fishes.
  26. ↑ The people's fish: Coelacanth genes get sequenced (May 10, 2013).
  27. ↑ Coelacanth genome informs land vertebrate evolution. ScienceDaily.
  28. ↑ Amemiya (April 29, 2013). "The African coelacanth genome provides insights into tetrapod evolution". Nature 496 (7445): 311–316. DOI:10.1038/nature12027. PMID 23598338. 
  29. ↑ Picone (September 29, 2014). "Taste and odorant receptors of the coelacanth--a gene repertoire in transition". Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution 322 (6): 403–414. DOI:10.1002/jez.b.22531. PMID 24106203. 
  30. ↑ Tsetse Fly Genome. www.uwc.ac.za.
  31. ↑ Christoffels (2014). "International Glossina Genome Initiative 2004–2014: A Driver for Post-Genomic Era Research on the African Continent - PMC". PLOS Neglected Tropical Diseases 8 (8): e3024. DOI:10.1371/journal.pntd.0003024. PMID 25144472. 
  32. ↑ Mwangi (September 22, 2015). "TSS seq based core promoter architecture in blood feeding Tsetse fly (Glossina morsitans morsitans) vector of Trypanosomiasis". BMC Genomics 16 (1): 722. DOI:10.1186/s12864-015-1921-6. PMID 26394619. 
  33. ↑ Masiga (2014). "Chemosensory receptors in tsetse flies provide link between chemical and behavioural ecology - PMC". Trends in Parasitology 30 (9): 426–428. DOI:10.1016/j.pt.2014.06.007. PMID 25017128. 
  34. ↑ Dashti (August 8, 2016). "Computational characterization of Iron metabolism in the Tsetse disease vector, Glossina morsitans: IRE stem-loops". BMC Genomics 17 (1): 561. DOI:10.1186/s12864-016-2932-7. PMID 27503259. 
  35. ↑ Murungi (April 1, 2014). "A comparative analysis of trypanosomatid SNARE proteins". Parasitology International 63 (2): 341–348. DOI:10.1016/j.parint.2013.11.002. PMID 24269876. 
  36. ↑ Butler (January 1, 2004). "African labs win major role in tsetse-fly genome project". Nature 427 (6973): 384. DOI:10.1038/427384b. PMID 14749791. 
  37. ↑ SANBI – 2015 Annual report.
  38. ↑ Vij (April 15, 2016). "Chromosomal-Level Assembly of the Asian Seabass Genome Using Long Sequence Reads and Multi-layered Scaffolding". PLOS Genetics 12 (4): e1005954. DOI:10.1371/journal.pgen.1005954. PMID 27082250. 
  39. ↑ Mbandi (February 21, 2015). "Inferring bona fide transfrags in RNA-Seq derived-transcriptome assemblies of non-model organisms". BMC Bioinformatics 16 (1): 58. DOI:10.1186/s12859-015-0492-5. PMID 25880035. 
  40. ↑ Bedeker (2019). "Understanding biobanking: An assessment of the public engagement speaking book intervention Biobanking and Me". South African Journal of Bioethics and Law 12 (2). DOI:10.7196/SAJBL.2019.v12i2.691. 
  41. ↑ SA's top researchers honoured. SAnews (August 28, 2015).
  42. ↑ Broad Institute | Fulbright Scholar Program. fulbrightscholars.org.
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