Cinazepam
Cinazepam (BD-798, nke a na-ere n'okpuru aha Levana) bụ ihe na-adịghị ahụkebe nke benzodiazepine.[1] Ọ na-emepụta mmetụta hypnotic, sedative, na anxiolytic na obere mmetụta myorelaxant na ụdị nke ụwa na ngwa mma na onye isi oche nkeji nke ụmụaka hụrụ.[2][3][4] Na mgbakwunye, n'adịghị ka ọtụtụ ọgwụ ndị ọzọ na-adịghị na ụdị nke ụwa họrọ site na iji bịa na ímé ihe nọr na mkpóró ndị na eme ka benzodiazepine hypnotics dị ka diazepam, flunitrazepam, na zopiclone, cinazepam anaghị emebi usoro ụra, na ịga n'ihu nke ụra na-adịghị ngwa ngwa na ụra REM na-abawanye.[2][3][4] N'ihi nke a, cinazepam na-emepụta ọnọdụ ụra dị nso na nke ahụ, na n'ihi nke ahu ndi, ọ nwere ike ịba uru ma e jiri ya tụnyere ọgwụ ndị ọzọ, ndị metụtara ya na ọgwụgwọ nke ehighị ụra na nsogbu ụra ndị ọzọ.[2]
Cin<sub id="mwLQ">a</sub>zepam nwere usoro dị ala maka onye na-anabata benzodiazepine nke mgbagwoju GABAA ma e jiri ya tụnyere benzodiazepines ndị ọzọ a ma ama dị ka nitrazepam na phenazepam.[2] Ọzọkwa, na ụmụ oke, a na-agbari ya ngwa ngwa, naanị 5% nke isi ihe fọdụrụ n'ime nkeji 30 nke nchịkwa.[2] N'ihi ya, a na-ewere cinazepam dị ka ọgwụ benzodiazepine; ọkachasị, na 3-hydroxyphenazepam, dị ka isi metabolite na-arụ ọrụ.[2]
Hụkwa[dezie | dezie ebe o si]
- Gidazepam
- Cloxazolam
Ntụaka[dezie | dezie ebe o si]
- ↑ (1997) Sleep Research. Brain Information Service/Brain Research Institute, University of California..
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 (2011) "Elimination kinetics of the novel prodrug cinazepam possessing psychotropic activity in mice". Pharmacological Reports 63 (5): 1093–1100. DOI:10.1016/s1734-1140(11)70628-4. PMID 22180351.
- ↑ 3.0 3.1 (2007) "Effect of cinazepam administration on the ligand affinity of neuromediator system receptors in rat brain". Pharmaceutical Chemistry Journal 41 (5): 249–252. DOI:10.1007/s11094-007-0055-9. ISSN 0091-150X.
- ↑ 4.0 4.1 (1998) "Bioaccessibility of cinazepam introduced as inclusion complex with β-cyclodextrin". Pharmaceutical Chemistry Journal 32 (10): 513–515. DOI:10.1007/BF02465736. ISSN 0091-150X.