Fenadiazole
Fenadiazole (INN), nke a makwaara dị ka phénadiazole (DCF) ma na-ere n'okpuru aha Hypnazol, Eudormil, na Viodor, bụ ọgwụ na-eme ka mmadụ kwụsị ịlụso ehighị ụra nke a na-eji agwọ ma anaghịzi ere ahịa.[1][2][3][4][5][6][7] A na-akọwa ya dị ka ọgwụ na-abụghị barbiturate hypnotic nke nwere akara ma ọ bụ ihe dị omimi na ọgwụgwọ n'ime ụmụ anụmanụ, mmetụta hypnotic dịgasị iche iche n'ime mmadụ (na-akpali ụra ngwa ngwa gbaba n'ebe nile site n'ime ụmụ ndị ogbi ozi ọma ahụ n'ebe nile maka awa 6 ruo 8), ihe mgbochi mgbochi, na mmetụta spasmolytic, na profaịlụ na-anagide nke ọma n'ime ndị mmadụ (na nkezi nke 200 mg / ụbọchị).[7][8] Ọgwụ ahụ mepụtara, kọwaa ya na ọgwụ, mepụtara ya, mepụtara, ma na-ere ya site na ụlọ ọrụ na-emepụta ọgwụ na France bụ Laboratoires Jacques Logeais n'etiti afọ 1960 na 1962.[2][9][3][6] Dị ka ihe na-eme ka mmadụ kwụsị ma na-eme ihe na-adịghị ndị mmadụ mma, fenadiazole nwere usoro kemịkal pụrụ iche nke sitere na oxadiazole.[10] Ọ nwere ike ịbelata ọtụtụ ndị na eme na ohiri ike ịbụ na ọ nwere njikọ kemịkalụ na ọgwụ ndị ọzọ na-eme ka mmadụ kwụsị ịrapara mmadụ n'ahụ na ọ bụghị ihe a na-ahụkarị.[10][7]
Ntụaka
[dezie | dezie ebe o si]- ↑ (1949) Nordisk veterinärmedicin. Nordisk veterinærmedicin. OCLC 1638883. “Fenadiazolum (DCF, pINN). 2-(2-Hydroxyphenyl)-1,3,4-oxadiazol. Fenadiazol. DCF: Phénadiazole R: Hypnazol (Hypnoticum).”
- ↑ 2.0 2.1 (14 November 2014) The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer, 662–. ISBN 978-1-4757-2085-3. OCLC 1058412474. “2-(2-Hydroxyphenyl)-1,3,4-oxadiazole H-00192. o-1,3,4-Oxadiazol-2-ylphenol, 8CI. Fenadiazole, INN. Hypnazol. Eudormil. Viodor. JL 512. [1008-65-7]. C8H6N2O2 M 162.148. Hypnotic, sedative. Mp 111-112°. Bp0.1 180°. ▷SM5850000. Maillard, J. et al, Bull. Soc. Chim. Fr., 1961, 529 (synth). Vincent, M. et al, Bull. Soc. Chim. Fr., 1962, 1580 (synth, pharmacol).”
- ↑ 3.0 3.1 (1996) The Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals, 12th, Whitehouse Station, NJ: Merck Research Laboratories. ISBN 978-0-911910-12-4. “3898. Fenadizole. 2-(1,3,4-Oxadiazol-2-yl)phenol; 2-(o-hydroxyphenyl)-1,3,4-oxadiazole; Hypnazol. C8H6N2O2; mol wt 162.14. C 59.26%, H 3.73%, N 17.27%, O 19.74%. Prepn: Maillard et al., Bull. Soc. Chim. France 1961, 529; Vincent et al., ibid. 1962, 1580; Brit. pat. 902,388 and Maillard et al., Fr. pat. M379, C.A. 57, 15251g (1962) (both 1962 to Logeais Labs.). [Chemical structure figure] Crystals from methanol. mp 111–112°. bp0.1 180°. LD50 i.p. in mice: 940 mg/kg. THERAP CAT: Hypnotic.”
- ↑ (1978) Organic-chemical Drugs and Their Synonyms: An International Survey, Volume 1, 5, Akademie-Verlag. ISBN 978-0-89573-100-5. OCLC 4208605. “2-(o-Hydroxyphenyl)-1,3,4-oxadiazol S Eudormil, Fenadiazol**, Hypnazol, J.L. 512, Phénadiazole, Viodor V Hypnoticum, Sedativum”
- ↑ (1961) "Unknown". Journal de médecine de Bordeaux et de la région du sud-ouest ...: Fondé en 1829 138.
- ↑ 6.0 6.1 Society of Chemical Industry (Great Britain) (1960). Reports on the Progress of Applied Chemistry. Society of Chemical Industry. OCLC 1765911. “Yet another new type of compound, 2-o-hydroxy-1,3,4-oxadiazole (Hypnazol) has hypnotic properties and has been used successfully in the treatment of insomnia (8).”
- ↑ 7.0 7.1 7.2 (1963) Les hypnotiques. Presses universitaires de France. OCLC 14552633. “Les hypnotiques suivants sont des substances diazotées, c'est-à-dire qu'elles renferment 2 N dans leur constitution: L'hypnazole: soporifique modérateur de l'activité spontanée, anticonvulsivant, antithermique et spasmolytique; Le révonal, dérivé de la quinazolinone, possède expérimentalement une activité hypnotique, analgésique, anti-inflammatoire et antipyrétique.”
- ↑ (1960) "A new nonbarbiturate hypnotic, 2-(o-hydroxyphenyl)-1,3,4-oxadiazole.". Revue Médicale de Nancy 85: 413–418.
- ↑ Kpọpụta njehie: Invalid
<ref>tag; no text was provided for refs namedGB902388 - ↑ 10.0 10.1 (31 December 1997) "3.3 Hypnotics and Sedatives Not Belonging to the Classes of Barbiturates and Benzodiazepines", Analytical Toxicology for Clinical, Forensic and Pharmaceutical Chemists. Walter de Gruyter, 399–426. DOI:10.1515/9783110881615.399. ISBN 978-3-11-010731-9. OCLC 1091453690. “2-(l,3,4-Oxadiazol-2-yl)phenol, 2-(o-hydroxyphenyl)-l,3,4-oxadiazole, Fenadiazole, Hypnazole (Hypnotic). [...] Other compounds used as hypnotics or sedatives are tribromomethane (bromoform), hydrobromic acid, phenyl-methyl-ketone (acetophenone), the imidazole derivative Etomidate, the oxadiazole derivative Fenodiazole (Hypnazole) and the sulfones Sulfonal (Sulfomethane) and Ethylsulfonal (Trional) (table 9).”