Ihe na-egbu egbu
Vornorexant, nke a makwaara site na aha koodu mmepe ya ORN-0829 na TS-142, bụ ọgwụ na-emegide orexin nke na-emepe emepe maka ọgwụgwọ nke ụwa họrọ site na iji bịa na ímé ihe nọr ehighị ụra na apnea ụra.[1][2][3] Ọ bụ onye na-emegide orexin abụọ OX1 na OX2 receptor antagonist (DORA).[3][4] A na-aṅụ ọgwụ ahụ n'ọnụ.[5] Ka ọ na-erule n'ọnwa Juun 2021, vornorexant nọ na nyocha nke abụọ maka ehighị ụra nke ọma na nyocha nke mbụ maka apnea ụra.[1] Ọ na-emepe emepe site na Taisho Pharmaceutical.[1]
Vornorexant nwere oge kachasị elu nke awa 2.5 na obere oge mkpụmkpụ ụkwụ maka ịkụrụ ndị mmadụ n'ihe nke 1.3 ruo 3.3 awa.[5][6] E mere ya ka ọ nwee ọkara ndụ dị mkpirikpi na oge iji belata mmetụta ndị ọzọ dị ka ụra.[3]
Hụkwa[dezie | dezie ebe o si]
- Seltorexant - onye ọzọ na-eme nchọpụta na-adịghị arụ ọrụ nke ọma na-emegide onye na-anabata orexin
- Ndepụta nke ọgwụ ụra nyocha § Orexin receptor antagonists
Nt[dezie | dezie ebe o si]
- ↑ 1.0 1.1 1.2 TS 142 - AdisInsight.
- ↑ (November 2020) "Clinical pharmacology, efficacy, and safety of orexin receptor antagonists for the treatment of insomnia disorders". Expert Opin Drug Metab Toxicol 16 (11): 1063–1078. DOI:10.1080/17425255.2020.1817380. PMID 32901578.
- ↑ 3.0 3.1 3.2 (January 2022) "Hypocretins (orexins): The ultimate translational neuropeptides". J Intern Med. DOI:10.1111/joim.13406. PMID 35043499.
- ↑ (July 2020) "Discovery of ORN0829, a potent dual orexin 1/2 receptor antagonist for the treatment of insomnia". Bioorg Med Chem 28 (13): 115489. DOI:10.1016/j.bmc.2020.115489. PMID 32482533.
- ↑ 5.0 5.1 (March 2022) "Effects of TS-142, a novel dual orexin receptor antagonist, on sleep in patients with insomnia: a randomized, double-blind, placebo-controlled phase 2 study". Psychopharmacology (Berl). DOI:10.1007/s00213-022-06089-6. PMID 35296912.
- ↑ Uchiyama (April 2020). "0146 Efficacy and Safety of Single Dose of TS-142, a Novel and Potent Dual Orexin Receptor Antagonist, in Insomnia Patients". Sleep 43 (Supplement 1): A58–A58. DOI:10.1093/sleep/zsaa056.144. ISSN 0161-8105.