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Joseph Yanai

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Joseph Yanai

Joseph Yanai bụ onye nchọcha na-asụ ụzọ n'ịmụ mweghachi nke mmerụ nwa neurobehavioral n'ụdị anụmanụ. [1] Ọ na-eje ozi dị ka onye prọfesọ na onye isi nke Ross Laboratory for Studies in Neural Birth Defects na Department of Medical Neurobiology, The Institute for Medical Research, Israel-Canada (IMRIC) na Hebri University-Hadassah Medical School Jerusalem, Israel ma bụrụkwa ya. họpụtara dị ka prọfesọ ọzọ, Ngalaba Na -ahụ Maka Ọgwụ na Ọrịa Cancer, Ụlọ Akwụkwọ Ọgwụ nke Mahadum Duke, Durham, NC, US.

Ọrụ nyocha

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Kemgbe afọ 1973, ọ so na ndị mbụ na-amụ banyere nkwarụ ọmụmụ omume. [2] Usoro ọhụụ ya bụ ịmụ usoro nke ụfọdụ neuroteratogens na-ebute mmetụta ha na-emebi emebi, na-elekwasị anya na ntụpọ omume nke na-arụ ọrụ nke metụtara septohippocampal cholinergic innergic. [3] Nsonaazụ gosiri mgbanwe na cholinergic neurotransmission cascade na-agbakọta n'ime mwepu nke cholinergic receptor-induced activation/translocation PKC. [4] Site n'ịchọpụta usoro nke neuroteratogenicity, ọ rụtụrụ aka n'akwụkwọ ya "neurobehavioral teratology." [5] maka ọdịnihu nke ubi site n'ịmepụta echiche nke "Neurobehavioral teratology. Ọzọkwa, Yanai kwusiri ike na ịghọta usoro nke ntụpọ mmepe ga-emecha mee ka ọ gbanwee ya, echiche nke yiri akụkọ sayensị na 1984.

Kpọmkwem kemgbe 1987, Yanai emepụtala ụdị anụmanụ maka ngbanwe nke mmebi ọmụmụ nke neurobehavioral, na-amalite site na ịmegharị nke A10 septal dopaminergic innervation, [6] nicotine therapy, [7] ma nke kachasị mkpa, site na ntụgharị nke sel na ụbụrụ na-adịghị mma. Ndị a gụnyere mkpụrụ ndụ ụbụrụ dị iche iche nke nwa ebu n'afọ (neural grafting), [8] na ọmụmụ ihe ndị na-esote, mkpụrụ ndụ stem sitere na mmalite dị iche iche: embrayo, mkpụrụ ndụ akwara neural, [9] sel sel ventricular subventricular, [10] na mkpụrụ ndụ mesenchymal. [11] [12] Mgbanwe nke mkpụrụ ndụ n'ụdị ọ bụla tụgharịrị erughị eru omume butere tupu ọmụmụ yana mgbanwe akwara metụtara usoro. Nnyocha ndị ọzọ na-atụ aro na otu isi usoro nke mkpụrụ ndụ stem na-arụ ọrụ ọgwụgwọ ha bụ site n'ịkwalite neurogenesis. [13] [14]

E bipụtara nchoputa ndị a na akwụkwọ akụkọ na-eduga (dịka ọmụmaatụ Molecular Psychiatry, [15] ) ma nata mgbasa ozi mgbasa ozi zuru oke (njikọ mpụga [16] [17] ) ma gosipụta ya na isi okwu akpọrọ, na nnọkọ mba ụwa na San Antonio, Texas, na June 2016. [18] Nyochaa ọrụ Yanai na ọganihu na ngbanwe nke neurobehavioral teratology nke ụlọ nyocha ndị ọzọ kwalitere na 2019 [19] na Basel, Switzerland na February 2017.

Ntụaka

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  1. ↑ Yanai (August 2019). "Reversal of neurobehavioral teratogenicity in animal models and human: Three decades of progress". Brain Research Bulletin 150: 328–342. DOI:10.1016/j.brainresbull.2019.06.009. ISSN 0361-9230. PMID 31207281. 
  2. ↑ (December 1973) "Behavior genetics association abstracts". Behavior Genetics 3 (4): 393–419. DOI:10.1007/bf01070223. ISSN 0001-8244. 
  3. ↑ (December 1973) "Behavior genetics association abstracts". Behavior Genetics 3 (4): 393–419. DOI:10.1007/bf01070223. ISSN 0001-8244. 
  4. ↑ Yanai (October 2004). "Convergent Effects on Cell Signaling Mechanisms Mediate the Actions of Different Neurobehavioral Teratogens: Alterations in Cholinergic Regulation of Protein Kinase C in Chick and Avian Models". Annals of the New York Academy of Sciences 1025 (1): 595–601. DOI:10.1196/annals.1316.074. ISSN 0077-8923. PMID 15542768. 
  5. ↑ (1984) in Joseph Yanai: Neurobehavioral teratology. Amsterdam: Elsevier. ISBN 0-444-80516-8. OCLC 10275574. 
  6. ↑ Yanai (August 1989). "Dopaminergic denervation reverses behavioral deficits induced by prenatal exposure to phenobarbital". Developmental Brain Research 48 (2): 255–261. DOI:10.1016/0165-3806(89)90080-1. ISSN 0165-3806. PMID 2505945. 
  7. ↑ Beer (2004-10-20). "Nicotine Therapy in Adulthood Reverses the Synaptic and Behavioral Deficits Elicited by Prenatal Exposure to Phenobarbital". Neuropsychopharmacology 30 (1): 156–165. DOI:10.1038/sj.npp.1300582. ISSN 0893-133X. PMID 15496940. 
  8. ↑ Yanai (1988). "Neuron transplantation reverses phenobarbital-induced behavioral birth defects in mice". International Journal of Developmental Neuroscience 6 (5): 409–416. DOI:10.1016/0736-5748(88)90046-9. ISSN 0736-5748. PMID 3202000. 
  9. ↑ Kazma (2010-02-01). "Survival, differentiation, and reversal of heroin neurobehavioral teratogenicity in mice by transplanted neural stem cells derived from embryonic stem cells". Journal of Neuroscience Research 88 (2): 315–323. DOI:10.1002/jnr.22193. ISSN 0360-4012. PMID 19746435. 
  10. ↑ Turgeman (2011-04-21). "Reversal of chlorpyrifos neurobehavioral teratogenicity in mice by allographic transplantation of adult subventricular zone-derived neural stem cells". Journal of Neuroscience Research 89 (8): 1185–1193. DOI:10.1002/jnr.22631. ISSN 0360-4012. PMID 21520219. 
  11. ↑ Yanai (August 2019). "Reversal of neurobehavioral teratogenicity in animal models and human: Three decades of progress". Brain Research Bulletin 150: 328–342. DOI:10.1016/j.brainresbull.2019.06.009. ISSN 0361-9230. PMID 31207281. 
  12. ↑ Stem cell therapy may reverse brain birth defects (en). Oneindia.com (30 December 2008). Archived from the original on 6 August 2024. Retrieved on 6 August 2024.
  13. ↑ Health Scan: Stem cell therapy may reverse brain defects. The Jerusalem Post.
  14. ↑ Ben-Shaanan (2007-09-18). "Transplantation of neural progenitors enhances production of endogenous cells in the impaired brain". Molecular Psychiatry 13 (2): 222–231. DOI:10.1038/sj.mp.4002084. ISSN 1359-4184. PMID 17876325. 
  15. ↑ Ben-Shaanan, TL, Ben-Hur, T, and Yanai, J.: “Transplantation of neural progenitors enhances production of endogeneous cells in the impaired brain”. Molecular Psychiatry, September 18, 2007. Vol. 13, No. 2, pp222-231
  16. ↑ Hebrew University Scientists Succeed Through Stem Cell Therapy in Reversing Brain Birth Defects (en). Technology Networks.
  17. ↑ Stem Cells Undo Birth Defects (en). MIT Technology Review.
  18. ↑ Yanai (May 2016). "Fortieth Anniversary Annual Meeting of the Developmental Neurotoxicology Society Held in Conjunction with the 56th Annual Meeting of the Teratology Society Grand Hyatt San Antonio, San Antonio, Texas June 25–29, 2016". Neurotoxicology and Teratology 55: 58–75. DOI:10.1016/j.ntt.2016.04.003. ISSN 0892-0362. 
  19. ↑ Yanai (August 2019). "Reversal of neurobehavioral teratogenicity in animal models and human: Three decades of progress". Brain Research Bulletin 150: 328–342. DOI:10.1016/j.brainresbull.2019.06.009. ISSN 0361-9230. PMID 31207281. 
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