Métaplasia eriri afọ

Métaplasia eriri afọ bụ mgbanwe (métaplasia) nke epithelium (na-abụkarị nke afọ ma ọ bụ esophagus) n'ime ụdị epithelium yiri nke a na-ahụ na eriri afọ. Na esophagus, a na-akpọ nke a esophagos nke Barrett. A na-ahụ ọzịza na-adịghị ala ala nke ọrịa H. pylori na afọ na GERD na esophagus dị ka ndị isi na-akpata metaplasia na mmepụta adenocarcinoma. Na mbido, epithelium gbanwere yiri obere eriri afọ; na ọkwa ndị ọzọ ọ yiri eriri afọ. A na-akọwa ya site na ọdịdị nke Mkpụrụ ndụ iko na ngosipụta nke akara mkpụrụ ndụ eriri afọ dị ka ihe transcription, CDX2.

Ihe ize ndụ

Ọ bụ ezie na a kọrọ na mbụ na ndị agbụrụ East Asia nwere metaplasia eriri afọ nọ n'ihe ize ndụ dị ukwuu nke Ọrịa kansa afọ, ^[1] ọ doro anya ugbu a na metaplasis eriri afọ bụkwa ihe ize ndụ na mpaghara ndị na-adịchaghị njọ dị ka Europe. ^[2] Ihe ize ndụ maka ọganihu nke metaplasia eriri afọ na ọrịa kansa zuru oke bụ ịṅụ sịga na akụkọ ezinụlọ.^[3]

Ịnọgwụgwụ

Mmetụta nke eriri afọ nke nwere mmeghachi omume Mmebi DNA na-arụ ọrụ nwere ike ịnwe ogologo oge na ọnọdụ premalignant ruo mgbe mmebi ahụ ga-eme ka mmeghachihachi omume mmeji DNA na-eduga na mgbasawanye clonal na ọganihu na kansa.^[4] N'oge mmeghachi omume mmebi DNA, a na-egosipụta protein ndị na-achọpụta mmebi DNA ma na-eme ka mmeghachihachi omume dị ka mmezi DNA, ebe nyocha nke mkpụrụ ndụ ma ọ bụ apoptosis.^[4]

Ihe odide

↑ Choi (April 2018). "Association of gastric intestinal metaplasia and East Asian ethnicity with the risk of gastric adenocarcinoma in a U.S. population.". Gastrointestinal Endoscopy 87 (4): 1023–1028. DOI:10.1016/j.gie.2017.11.010. PMID 29155082.
↑ (April 2019) "Surveillance of premalignant gastric lesions: a multicentre prospective cohort study from low incidence regions". Gut 68 (4): 585–593. DOI:10.1136/gutjnl-2017-314498. PMID 29875257.
↑ (March 2021) "Surveillance of premalignant gastric lesions: a multicentre prospective cohort study from low incidence regions". Endosc Int Open 9 (3): E297–E305. DOI:10.1055/a-1314-6626. PMID 33655025.
↑ ^4.0 ^4.1 Krishnan (October 2020). "DNA damage signalling as an anti-cancer barrier in gastric intestinal metaplasia.". Gut 69 (10): 1738-1749. DOI:10.1136/gutjnl-2019-319002. PMID 31937549.

Njikọ mpụga

Ntuziaka AGA Clinical Practice na Nchịkwa nke Gastric Intestinal Metaplasia
Intestinal metaplasia (nkọwa) - mondofacto.com.

[Choi-1] Choi (April 2018). "Association of gastric intestinal metaplasia and East Asian ethnicity with the risk of gastric adenocarcinoma in a U.S. population.". Gastrointestinal Endoscopy 87 (4): 1023–1028. DOI:10.1016/j.gie.2017.11.010. PMID 29155082.

[pmid_29875257-2] (April 2019) "Surveillance of premalignant gastric lesions: a multicentre prospective cohort study from low incidence regions". Gut 68 (4): 585–593. DOI:10.1136/gutjnl-2017-314498. PMID 29875257.

[pmid33655025-3] (March 2021) "Surveillance of premalignant gastric lesions: a multicentre prospective cohort study from low incidence regions". Endosc Int Open 9 (3): E297–E305. DOI:10.1055/a-1314-6626. PMID 33655025.

[Krishnan2020-4] 4.0 ^4.1 Krishnan (October 2020). "DNA damage signalling as an anti-cancer barrier in gastric intestinal metaplasia.". Gut 69 (10): 1738-1749. DOI:10.1136/gutjnl-2019-319002. PMID 31937549.

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