Métaplasia eriri afọ
Métaplasia eriri afọ bụ mgbanwe (métaplasia) nke epithelium (na-abụkarị nke afọ ma ọ bụ esophagus) n'ime ụdị epithelium yiri nke a na-ahụ na eriri afọ. Na esophagus, a na-akpọ nke a esophagos nke Barrett. A na-ahụ ọzịza na-adịghị ala ala nke ọrịa H. pylori na afọ na GERD na esophagus dị ka ndị isi na-akpata metaplasia na mmepụta adenocarcinoma. Na mbido, epithelium gbanwere yiri obere eriri afọ; na ọkwa ndị ọzọ ọ yiri eriri afọ. A na-akọwa ya site na ọdịdị nke Mkpụrụ ndụ iko na ngosipụta nke akara mkpụrụ ndụ eriri afọ dị ka ihe transcription, CDX2.
Ihe ize ndụ[dezie | dezie ebe o si]
Ọ bụ ezie na a kọrọ na mbụ na ndị agbụrụ East Asia nwere metaplasia eriri afọ nọ n'ihe ize ndụ dị ukwuu nke Ọrịa kansa afọ, [1] ọ doro anya ugbu a na metaplasis eriri afọ bụkwa ihe ize ndụ na mpaghara ndị na-adịchaghị njọ dị ka Europe. [2] Ihe ize ndụ maka ọganihu nke metaplasia eriri afọ na ọrịa kansa zuru oke bụ ịṅụ sịga na akụkọ ezinụlọ.[3]
Ịnọgwụgwụ[dezie | dezie ebe o si]
Mmetụta nke eriri afọ nke nwere mmeghachi omume Mmebi DNA na-arụ ọrụ nwere ike ịnwe ogologo oge na ọnọdụ premalignant ruo mgbe mmebi ahụ ga-eme ka mmeghachihachi omume mmeji DNA na-eduga na mgbasawanye clonal na ọganihu na kansa.[4] N'oge mmeghachi omume mmebi DNA, a na-egosipụta protein ndị na-achọpụta mmebi DNA ma na-eme ka mmeghachihachi omume dị ka mmezi DNA, ebe nyocha nke mkpụrụ ndụ ma ọ bụ apoptosis.[4]
Ihe odide[dezie | dezie ebe o si]
- ↑ Choi (April 2018). "Association of gastric intestinal metaplasia and East Asian ethnicity with the risk of gastric adenocarcinoma in a U.S. population.". Gastrointestinal Endoscopy 87 (4): 1023–1028. DOI:10.1016/j.gie.2017.11.010. PMID 29155082.
- ↑ (April 2019) "Surveillance of premalignant gastric lesions: a multicentre prospective cohort study from low incidence regions". Gut 68 (4): 585–593. DOI:10.1136/gutjnl-2017-314498. PMID 29875257.
- ↑ (March 2021) "Surveillance of premalignant gastric lesions: a multicentre prospective cohort study from low incidence regions". Endosc Int Open 9 (3): E297–E305. DOI:10.1055/a-1314-6626. PMID 33655025.
- ↑ 4.0 4.1 Krishnan (October 2020). "DNA damage signalling as an anti-cancer barrier in gastric intestinal metaplasia.". Gut 69 (10): 1738-1749. DOI:10.1136/gutjnl-2019-319002. PMID 31937549.
Njikọ mpụga[dezie | dezie ebe o si]
- Ntuziaka AGA Clinical Practice na Nchịkwa nke Gastric Intestinal Metaplasia
- Intestinal metaplasia (nkọwa) - mondofacto.com.