Methoxyacetic acid
| obere ụdị nke | chemical compound  |
|---|---|
| usoro kemịkalụ | C₃H₆O₃ |
| canonical SMILES | COCC(=O)O |
Methoxyacetic acid bụ ihe sitere na acetic acid nke a na-eji otu methoxy dochie hydrogen atom nke otu methyl. Dị ka otu okwu methyl glycolic acid gosipụtara, na dị ka ether carboxylic acid kachasị mfe, enwere ike ịghọta methoxyacetic acid dị ka methyl ether nke glycolic acid.
N'ihi nnukwu ikike ya, a nabatara methoxyacetic acid n'ime ndepụta nke ihe SVHC (ihe ndị na-echegbu onwe ha) [1] ma debanye aha ya dị ka ngwaahịa dị n'etiti maka ebumnuche ụlọ ọrụ n'okpuru ọnọdụ a na-achịkwa nke ọma.
Maka ngwa ndị na-azụ ahịa, dị ka maka ihicha na decalcification nke elu, ihe a ga-eji ihe ndị ọzọ dị mma dochie ya.
Mmepụta
[dezie | dezie ebe o si]Site na okpukpu abụọ nke sodium methoxide na methanol, ntụgharị nke Monochloroacetic acid na-emepụta, mgbe acidization nke Hydrogen chloride gas kpọrọ nkụ na vacuum distillation, methoxyacetic acid na ọnụọgụ nke ihe dị ka 90%[2].
Ụzọ nke njikọ adịghị arụ ọrụ nke ọma n'ihi na ọ chọrọ ihe ndị dị oke ọnụ na nnukwu ego nke ngwaahịa sodium chloride.
Mgbe [3] na-eji nitric acid concentrated eme ka methyl glycol oxide - ọbụlagodi na vanadium (V) oxide - a na-emepụta methoxyacetic acid na ọnụego nke ihe dị ka pasenti iri asatọ na ise.
Ihe na-adịghị mma nke mmeghachi omume site na iji (karịa ala) nitric acid na-ekpo ọkụ bụ mmepụta nke gas nitrous, nke - dị ka nitric acid gabigara ókè site na mgbakwunye nke urea na formaldehyde - a ghaghị izere.
Usoro a na-ahụkarị site na ụkpụrụ ụlọ ọrụ bụ oxidation nke methyl glycol na ikuku ma ọ bụ Oxygen na ọnụnọ nke platinum catalysts na ihe dị elu (10-30%) mmiri na pH nke ≤ 7 na okpomọkụ gburugburu 50 °C, na-emepụta ihe ruru 95% na ohere-oge nke 150 g · 1-1-1[4].
N'ime ụmụ mmadụ na ụmụ anụmanụ, 2-methoxyacetic acid na-emepụta site na ngwa ngwa oxidation nke 2-metho xyethanol (methyl glycol) [5] site na alcohol dehydrogenases.
Ihe onwunwe
[dezie | dezie ebe o si]Methoxyacetic acid bụ mmiri doro anya, enweghị agba, viscous, na mmiri na-emebi emebi nwere isi ísì nke, na 7 Celsius C, na-ajụ oyi ka ọ bụrụ oke yiri glacial acetic acid. N'ihi ike ngwọta dị ala nke otu methoxy ya, methoxyacetic acid, nke nwere pKa uru nke 3.57, bụ acidic karịa acetic acid (pKa 4.757) na glycolic acid (pKa 3.832). [6].
[7] ike inweta ultra-pure methoxyacetic acid (purity of 99.8%, freezing point of 8.4 °C) site na multi-step crystallization nke raw distillate, nke na-enweghị mmetọ acid.
mmejuputa
[dezie | dezie ebe o si]N'ihi njirimara reprotoxic ya, ngwa ndị na-azụ ahịa na mbụ nke methoxyacetic acid dị ka ihe na-egbu egbu, biocide, ma ọ bụ dị ka ihe na-ehicha ihe maka nbibi nke elu adịkwaghịzi. Otú ahụ ka ọ dịkwa maka ihe ndị dị ka ihe mgbaze 2-methoxyethanol ma ọ bụ PVC plasticizer bis (2-methoxyethyl) phthalate, bụ nke a na-emepụta na methoxyacetic acid n'ime ahụ.
Dị ka akụkụ molekụla nke ọtụtụ ogige aromatic iodized, a na-eji methoxyacetic acid mee ihe n'otu oge na ihe dị iche iche nke X-ray.[8]
[9] nnwale ụlọ nyocha, methoxyacetic acid na-egbochi uto nke mkpụrụ ndụ akpụ.
Edensibia
[dezie | dezie ebe o si]- ↑ Substance Information - ECHA (en-GB). echa.europa.eu. Retrieved on 2023-12-05.
- ↑ Espacenet – search results. worldwide.espacenet.com. Archived from the original on 2023-12-05. Retrieved on 2023-12-05.
- ↑ Espacenet – search results. worldwide.espacenet.com. Archived from the original on 2023-12-05. Retrieved on 2023-12-05.
- ↑ Espacenet – search results. worldwide.espacenet.com. Archived from the original on 2023-12-05. Retrieved on 2023-12-05.
- ↑ Mebus (1989). "The possible role of one-carbon moieties in 2-methoxyethanol and 2-methoxyacetic acid-induced developmental toxicity" (in en). Toxicology and Applied Pharmacology 99 (1): 98–109. DOI:10.1016/0041-008X(89)90115-4. PMID 2471293.
- ↑ King (1960). "The Thermodynamics of Ionization of Amino Acids. V. The Ionization Constants of 3-Methoxy-DL-alanine (O-Methylserine) and Methoxyacetic Acid 1" (in en). Journal of the American Chemical Society 82 (14): 3575–3578. DOI:10.1021/ja01499a025. ISSN 0002-7863.
- ↑ Espacenet – search results. worldwide.espacenet.com. Archived from the original on 2023-12-05. Retrieved on 2023-12-05.
- ↑ Espacenet – search results. worldwide.espacenet.com. Archived from the original on 2023-12-05. Retrieved on 2023-12-05.
- ↑ Parajuli (2014). "Methoxyacetic acid suppresses prostate cancer cell growth by inducing growth arrest and apoptosis". American Journal of Clinical and Experimental Urology 2 (4): 300–312. ISSN 2330-1910. PMID 25606576.