MiR-206

Shí Wikipedia, njikotá édémédé nke onyobulạ
Ọdịdị nke pre-miR-206 dị ka algorithms folding RNA kpebiri
Ihe njirimara maka usoro miR-206 na nchekwa data dị iche iche nke RNA na genomic

MiR-206 bụ microRNA nwere usoro echekwara n'ọtụtụ ụdị anụmanụ na-enye nwa ara, na ụmụ mmadụ bụ onye otu ezinụlọ myo-miR nke miRNAs, nke gụnyere miR-1, miR-133, na miR-208a / b.[1][2][3][4] Mir-206 guzobere nke ọma maka ịchịkwa usoro mkpụrụ ndụ nke metụtara mmepe nke ọkpụkpụ, yana ọrụ mitochondrial. na-amụ miR-206 na mkpụrụ ndụ C2C12 myoblast n'ihi na nke a bụ ihe nlereanya a na-ejikarị eme ihe maka ọmụmụ nke Ọdịiche nke mkpụrụ ndụ nke uru ọkpụkpụ.[5] Biogenesis nke miR- pụrụ iche n'ihi na a na-emepụta transcript mbụ tozuru etozu site na ogwe aka 3p nke microRNA hairpin karịa ogwe aka 5p.[6] Ka ọ dị ugbu a, miR-206 nwere ihe dịka ndị otu ezinụlọ miRNA iri na abụọ (nke isii n'ime ha gosipụtara na Tebụl 1), a na-echekwa usoro mkpụrụ osisi (nucleotides 2-8) nke ezinụlọ miR-206.

bụ ezie na a na-achịkwa miR-206 nke ọma n'oge mmepe embryonic nke uru ọkpụkpụ, miR-206, na-achịkwakwa site na onye na-anabata homonụ steroid nuklia 17β-estradiol.[7][8] Ihe akaebe ọzọ na-akwado ọrụ nke miR-206 na tumorigenesis sitere na ọmụmụ ihe na-egosi na miR-206, gosipụtara nke ọma na akpụ ara atọ na-adịghị mma nke na-etolite na-enweghị 17β-estradiol ma e jiri ya tụnyere estrogen-receptor positive (ERα +), 17β-estadiol sensitive breast cancer cells. miR-206 bụkwa ihe -egosi ọnụ ọgụgụ dị ala nke ndị na-adị ndụ n'ozuzu ha na ndị ọrịa kansa ara.[9]Bụ ezie na miR-206 nwere ọrụ akọwapụtara nke ọma na etiology nke akpụ ara, e gosipụtara miR-206, n'oge na-adịbeghị anya iji chịkwaa ọganihu mesothelioma site na nhazi nke ụzọ mgbaàmà Ras.[10] Nnyocha ndị a na-agbakwunye na akwụkwọ na-arịwanye elu na-egosi otú obere RNAs na-achịkwa na-ejigide usoro mkpụrụ ndụ nkịtị nke na-egbochi usoro tumorigenic. Ọtụtụ akara mkpụrụ ndụ eji akọwa ọrụ nke miR-206 na ọrịa kansa ara gụnyere MCF-7, MDA-MB-231, na akara mkpụrụ ndụ MDA- MB-468.

Enwere ike ịchọta Otu nucleotide polymorphisms (SNPs) na usoro mkpụrụ miRNA, ya mere amaara na ọ nwere nsonaazụ ọrụ. Otu 'ime mmetụta ndị dị otú ahụ bụ mgbanwe njikọ nke miRNA na mRNA jikọtara ya dabere na mgbanwe nke otu nucleotide nke mpaghara mkpụrụ miRNA.[11] N'ezie, ọtụtụ ọmụmụ egosiwo na usoro mkpụrụ nke miRNA abụghị naanị ihe a kapịrị ọnụ na mmekọrịta miRNA:mRNA, dịka mgbanwe nke ihe ndị fọdụrụ na mpụga mpaghara mkpụrụ nwekwara ike ịgbanwe ịdị irè a. Nchịkwa miR-206 nke ERα site na njikọ kpọmkwem nke miR-202 na ERα 3' UTR,[7] bụ ezigbo ihe atụ nke otu SNPs nwere ike isi metụta mmekọrịta miRNA:mRNA.

Chọpụtala ọtụtụ modulu nchịkwa miR-206 ndị ọzọ, dị ka lncRNA HOTAIR na-achịkwa Bcl-w site na sequestration nke miR-206, nke na-eme ka mmụba nke mkpụrụ ndụ na mkpụrụ ndụ kansa ara.[12] Nnyocha a na-egosi na miR-206 nwere ike imekọrịta ihe na RNA ndị ọzọ na-abụghị koodu iji chịkwaa usoro dịgasị iche iche nke tumorigenic n'ọtụtụ usoro kansa. Iji kw nke a, SNHG14 nwekwara ike sponge miR-206 si otú a gbanwee ụbara nke YWHAZ na ọrịa kansa akpa nwa.[13] N'ozuzu, ọmụmụ ihe ndị a na ọtụtụ ọmụmụ a na-edeghị ebe a n'ihi oke ohere, na-egosi n'ụzọ doro anya ikike ọgwụgwọ nke miRNA dịka miR-206 na ọnọdụ oncological.

N'èzí ngalaba nke ihe ndị dị ndụ, miR-206 nwere mmasị na ahụike n'ihi nchọpụta na-aga n'ihu nke miRNA a na nlele sitere na ndị nwere ụdị ọrịa shuga 2 (TIID) na ọrịa imeju na-abụghị mmanya (NAFLD). N'ime ọmụmụ ụfọdụ, nnyefe ọgwụgwọ nke miR-206 na ụdị òké buru ibu na-eri nri mere ka mmepụta abụba na glucose belata n'ime imeju. Ikike nke miR-206 iji mee mgbaàmà insulin dị mfe na gbanwee lipogenesis na-egosi na miR-202 nwere ike ịbụ ọgwụgwọ ọhụrụ maka ndị nwere hyperglycemia.[14] 'oge na-adịbeghị anya, a chọpụtakwala Mir-206 dị ka ihe na-egosi ọrịa ụfọdụ na-emetụta akụkụ ahụ,[15] ebe ọkwa miR-206 na-agbasa na preeclampsia. [16]

Nchekwa metụtara ndị ezinụlọ miR-206

Ihe odide[dezie | dezie ebe o si]

  1. ↑ (April 2007) "Control of stress-dependent cardiac growth and gene expression by a microRNA". Science 316 (5824): 575–9. DOI:10.1126/science.1139089. PMID 17379774. 
  2. ↑ (March 2010) "Regulation of PI3-kinase/Akt signaling by muscle-enriched microRNA-486". Proceedings of the National Academy of Sciences of the United States of America 107 (9): 4218–23. DOI:10.1073/pnas.1000300107. PMID 20142475. 
  3. ↑ (November 2009) "A family of microRNAs encoded by myosin genes governs myosin expression and muscle performance". Developmental Cell 17 (5): 662–73. DOI:10.1016/j.devcel.2009.10.013. PMID 19922871. 
  4. ↑ (2004) "Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation". Genome Biology 5 (3): R13. DOI:10.1186/gb-2004-5-3-r13. PMID 15003116. 
  5. ↑ Yaffe (Dec 22–29, 1977). "Serial passaging and differentiation of myogenic cells isolated from dystrophic mouse muscle". Nature 270 (5639): 725–727. DOI:10.1038/270725a0. ISSN 0028-0836. PMID 563524. 
  6. ↑ (January 2014) "miRBase: annotating high confidence microRNAs using deep sequencing data". Nucleic Acids Research 42 (Database issue): D68–73. DOI:10.1093/nar/gkt1181. PMID 24275495. 
  7. ↑ 7.0 7.1 (August 2009) "The role of miR-206 in the epidermal growth factor (EGF) induced repression of estrogen receptor-alpha (ERalpha) signaling and a luminal phenotype in MCF-7 breast cancer cells". Molecular Endocrinology 23 (8): 1215–30. DOI:10.1210/me.2009-0062. PMID 19423651. 
  8. ↑ (May 2007) "The micro-ribonucleic acid (miRNA) miR-206 targets the human estrogen receptor-alpha (ERalpha) and represses ERalpha messenger RNA and protein expression in breast cancer cell lines". Molecular Endocrinology 21 (5): 1132–47. DOI:10.1210/me.2007-0022. PMID 17312270. 
  9. ↑ (July 2008) "miR-206 Expression is down-regulated in estrogen receptor alpha-positive human breast cancer". Cancer Research 68 (13): 5004–8. DOI:10.1158/0008-5472.CAN-08-0180. PMID 18593897. 
  10. ↑ Singh (2021-06-04). "MicroRNA-206 suppresses mesothelioma progression via the Ras signaling axis" (in English). Molecular Therapy: Nucleic Acids 24: 669–681. DOI:10.1016/j.omtn.2021.04.001. ISSN 2162-2531. PMID 33996251. 
  11. ↑ (July 2007) "MicroRNA targeting specificity in mammals: determinants beyond seed pairing". Molecular Cell 27 (1): 91–105. DOI:10.1016/j.molcel.2007.06.017. PMID 17612493. 
  12. ↑ Ding (2017-12-08). "Long Noncoding RNA HOTAIR Modulates MiR-206-mediated Bcl-w Signaling to Facilitate Cell Proliferation in Breast Cancer" (in en). Scientific Reports 7 (1): 17261. DOI:10.1038/s41598-017-17492-x. ISSN 2045-2322. PMID 29222472. 
  13. ↑ Ji (2019-04-01). "LncRNA SNHG14 promotes the progression of cervical cancer by regulating miR-206/YWHAZ" (in en). Pathology - Research and Practice 215 (4): 668–675. DOI:10.1016/j.prp.2018.12.026. ISSN 0344-0338. PMID 30611620. 
  14. ↑ (April 2017) "MicroRNA-206 prevents hepatosteatosis and hyperglycemia by facilitating insulin signaling and impairing lipogenesis". Journal of Hepatology 66 (4): 816–824. DOI:10.1016/j.jhep.2016.12.016. PMID 28025059. 
  15. ↑ Schlosser (2020-01-31). "Circulating miR-206 and Wnt-signaling are associated with cardiovascular complications and a history of preeclampsia in women". Clinical Science 134 (2): 87–101. DOI:10.1042/CS20190920. ISSN 1470-8736. PMID 31899480. 
  16. ↑ Pegoraro (2021-01-12). "Circulating miR-206 as a Biomarker for Patients Affected by Severe Limb Girdle Muscle Dystrophies". Genes 12 (1): 85. DOI:10.3390/genes12010085. ISSN 2073-4425. PMID 33445560. 
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