Michelle Linterman
| ụdịekere | nwanyị  |
|---|---|
| mba o sị | New Zealand |
| aha enyere | Michelle, Angela |
| aha ezinụlọ ya | Linterman |
| ụbọchị ọmụmụ ya | 10 Ọktoba 1983 |
| Ebe ọmụmụ | Christchurch |
| ọrụ ọ na-arụ | ọkà mmụta sayensị, immunologist |
| onye were ọrụ | Babraham Institute |
| ebe agụmakwụkwọ | Australian National University, Victoria University of Wellington |
Michelle Linterman (amụrụ 1983) bụ ọkà mmụta ọgwụ mgbochi ọrịa New Zealand. Ọ bụ onye ndu otu na Babraham Institute dị na United Kingdom, ebe ọ na-eme nyocha gbasara bayoloji nke nzaghachi etiti germinal mgbe ọgwụ mgbochi na ọrịa gasịrị.
Ndụ mmalite na agụmakwụkwọ
[dezie | dezie ebe o si]A mụrụ Linterman na Christchurch, New Zealand, ada Louisa na Robert Linterman, ma tolite na Waikanae . [1] Ọ malitere ọmụmụ ihe na-agụghị akwụkwọ na sayensị biomedical na Mahadum Victoria nke Wellington (VUW) n'otu oge na mgbanwe sayensị na-eme na genetics, [1] wee gụchaa na Bachelor of Biomedical Sciences degree na 2005. [2]
Linterman gara Canberra wee gụchaa akwụkwọ mmụta n'oge okpomọkụ na Carola Vinuesa na Mahadum Mba Ọstrelia (ANU). Linterman kwụsịrị ịnọ na ANU otu afọ iji rụọ ọrụ na mkpụrụ ndụ ihe nketa mmadụ, tupu ya ekpebie imecha akara mmụta doctorate. Ọ malitere ịrụ ọrụ ya na ụmụ oke ndị gbanwere mkpụrụ ndụ ihe nketa iji ghọta ọrịa nke ọma. Vinuesa ka achọpụtala RC3H1 na-eji ụmụ oke ndị a, Linterman kpebiri ịmụ ihe kpatara ụmụ oke ndị a ji nwee lupus systemic-dị ka ọrịa. N'oge ahụ, follicular B helper cell (Tfh) malitere na-adọta mmasị nyocha dị ukwuu. Tfh dị oke mkpa maka nhazi etiti germinal, yana ụmụ oke na ụlọ nyocha Linterman (ya na mutation Roquin san/san sanroque ) na-emepụta mkpụrụ ndụ Tfh ozugbo nke nyere aka na lupus erythematosus systemic nke kpagburu ụmụ oke ndị a. [1] [3] Ọ chọpụtara na akụkụ nke mkpụrụ ndụ Tfh ndị a gosipụtara FOXP3, ihe ntinye ederede na-etinye aka na nzaghachi usoro ahụ ji alụso ọrịa ọgụ. [1]
Linterman kwagara na Mahadum Cambridge dị ka onye nyocha postdoctoral, ebe ọ mụrụ usoro ihe omimi nke mkpụrụ ndụ Tfh. [4] [5] Ka usoro ndị na-akwado ụkpụrụ FOXP3 na-amasị Linterman, Linterman malitere inyocha mkpụrụ ndụ Tfh na vivo . [6]
Nnyocha na ọrụ
[dezie | dezie ebe o si]Linterman guzobere otu nnyocha na Babraham Institute, ebe ọ na-amụ germinal center biology na otú usoro ahụ ji alụso ọrịa ọgụ si emeghachi omume na ịgba ọgwụ mgbochi ọrịa. [7] [8] Ebe germinal bụ saịtị dị n'ime anụ ahụ dị ndụ (dịka ọmụmaatụ na splin, tonsils na lymph nodes) ebe mkpụrụ ndụ B na-amụpụta, na-emepụtaghachi ma dị iche iche ka usoro ahụ ji alụso ọrịa ọgụ na-anabata ọrịa. Ebe germinal na-akuziri usoro ahụ ji alụso ọrịa ọgụ ka esi emeghachi ngwa ngwa na nke ọma maka nje nje n'ọdịnihu, ma dịkwa oke mkpa maka nzaghachi dị mma maka ịgba ọgwụ mgbochi ọrịa. Ọnụ ọgụgụ nzaghachi etiti germinal na-ebelata na afọ, nke ka ukwuu n'ihi ọrụ nke mkpụrụ ndụ T. [9] Linterman na-enyocha ọrụ germinal center na ịka nká, yana otu ha si etolite anụ ahụ na-abụghị nke lymphoid. [10] Ọ chọpụtara na ọtụtụ ihe omume na-emepụta ebe germinal na-enyere aka ịmepụta ọgwụ mgbochi na-emeghachi omume. [11]
N'afọ 2019, e nyere Linterman onyinye nturu ugo nyocha Lister Institute maka mbọ ọ gbara ịghọta ọrịa flu. [11] [12] Ọ chọpụtara na ahụ na-emezigharị anụ ahụ ngụgụ iji nye aka na nzaghachi usoro ahụ ji alụso ọrịa ọgụ ma mepụta ọgwụ mgbochi. [11]
Akwụkwọ ndị ahọpụtara
[dezie | dezie ebe o si]Ntụaka
[dezie | dezie ebe o si]- ↑ 1.0 1.1 1.2 1.3 Van Emmenis (2023-06-12). "Michelle Linterman: We are always learning". Journal of Experimental Medicine 220 (7): e20230900. DOI:10.1084/jem.20230900. ISSN 0022-1007. PMID 37306687. Kpọpụta njehie: Invalid
<ref>tag; name "Van Emmenis 2023" defined multiple times with different content - ↑ Roll of graduates. Victoria University of Wellington (November 2023). Retrieved on 6 March 2024.
- ↑ Linterman (2009-03-16). "Follicular helper T cells are required for systemic autoimmunity" (in en). Journal of Experimental Medicine 206 (3): 561–576. DOI:10.1084/jem.20081886. ISSN 1540-9538. PMID 19221396.
- ↑ Linterman (2014-10-27). "CD28 expression is required after T cell priming for helper T cell responses and protective immunity to infection" (in en). eLife 3. DOI:10.7554/eLife.03180. ISSN 2050-084X. PMID 25347065.
- ↑ Dr Michelle Linterman (en-GB). Churchill College. Retrieved on 2024-03-05.
- ↑ Linterman (August 2011). "Foxp3+ follicular regulatory T cells control the germinal center response" (in en). Nature Medicine 17 (8): 975–982. DOI:10.1038/nm.2425. ISSN 1078-8956. PMID 21785433.
- ↑ Michelle Linterman | Babraham Institute. www.babraham.ac.uk. Retrieved on 2024-03-04.
- ↑ Our Stories: Michelle Linterman. www.nzwomen.co.uk. Retrieved on 2024-03-05.
- ↑ Linterman lab at Babraham Institute uncovers reasons why our vaccine response declines with age (en). Cambridge Independent (2023-05-25). Retrieved on 2024-03-05.
- ↑ Michelle Linterman » Babraham Institute. www.babraham.ac.uk. Retrieved on 2024-03-05.
- ↑ 11.0 11.1 11.2 Dr Michelle Linterman at Babraham Institute wins £250,000 Lister Prize for work on flu infection (en). Cambridge Independent (2019-07-14). Retrieved on 2024-03-05. Kpọpụta njehie: Invalid
<ref>tag; name ":0" defined multiple times with different content - ↑ Fellow Profile: Dr Michelle Linterman (en-GB). Lister Institute (2019-12-12). Retrieved on 2024-03-05.