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Mkpụrụ ndụ endothelial jikọtara ya na akpụ

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Nlegharị anya nke akwara ọbara metụtara akpụ n'ime ara mmadụ

Mkpụrụ ndụ endothelial jikọtara akpụ ma ọ bụ mkpụrụ ndụ endot helial (TECs) na-ezo aka na mkpụrụ ndụ ndị dị n'akụkụ Akwara ọbara jikọtara akpụ nke na-achịkwa ịgafe nke ihe oriri n'ime anụ ahụ gbara ya gburugburu .[1] N'ime ụdị ọrịa kansa dị iche iche, a chọpụtala na akwara ọbara ndị metụtara akpụ dị iche iche na akwara jini nkịtị na ọdịdị, ngosipụta mkpụrụ ndụ ihe nketa, na ọrụ n'ụzọ na-akwalite ọganihu ọrịa kansa.[2][3] E nwere mmasị dị ịrịba ama n'ịmepụta ọgwụgwọ ọrịa kansa nke na-eji ihe ndị a na-adịghị mma nke endothelium jikọtara ya na akpụ iji bibie akpụ.[3][2]

Ọdịdị na-adịghị mma

[dezie | dezie ebe o si]

A na-edepụta mkpụrụ ndụ endotilial nke akpụ (TECs) iji gosipụta njirimara ọdịdị na-adịghị mma dị ka akụkụ na-adịghị ike na projekshon saitoplasmic na-adịghị adị.[1] N'ime akwara ọbara nkịtị, a maara na mkpụrụ ndụ endotilial na-emepụta otu ngongo na-ejikọta ọnụ na-enweghị mkpuchi, mana TECs na-emepụta otu ngongo na-enweghị nhazi na njikọ, na-agbakarị ma na-agbasa gafee lumen iji kpuchie ndị agbata obi ha.[4] Na mgbakwunye na nke a, TECs na-egosi akara dị iche iche nke na-ekewapụ ha n'ụzọ doro anya na mkpụrụ ndụ endotilial. A na-akọwa karị akpu endotilium dị ka mozaic n'ihi ngosipụta ya na-adịghị mma nke akara mkpụrụ ndụ endotilial ọdịnala (CD31 na CD105), na-akwado ịdị adị nke oghere na-adịghị n'etiti mkpụrụ ndụ endotilial. [3][5] Na ọkwa anaghị ahụ anya , karịa ịhụ obere oghere mmetụta mkpụrụ ndụ n'etiti TECs dị nso, akọwaala oghere dị ukwuu na mgbidi nke akpụ akwara ọbara[1][1]

A na-akọwa ọtụtụ akpụ site na ngosipụta dị elu nke vascular endothelial growth factor (VEGF), nke bụ vasodilator siri ike. E gosipụtara na VEGF na-akpali ntolite na isi alaka na mkpụrụ ndụ endothelial, na-eduga na otu ngongo endotheliel nwere nkwarụ.[6] Nnyocha na-akwado na mkpakọ nke akwara akpụ site na mkpụrụ ndụ akpụ gbara ya gburugburu na-ebute nrụgide na mgbanwe na ọbara.[7] A tụwo aro na mgbanwe ndị a na-agafe agafe na-akpata ngosipụta na-adịghị mma nke ihe ndị na-eme ka ọdịdị endothelial, nha, na ọdịiche dị iche iche.[8]

A na-ejikarị perisaiti s na-akwado ya na-agba obere ọwa ọbara

gburugburu nke na-enyere aka na nkwụsi ike nke arịa.[9] Mfu nke ihe na-eto eto pericyte (PDGFB) na onye na-anabata ya na mkpụrụ ndụ endothelial bụ mgbanwe nke ọkwa nke nwere ike ịkọwa maka mfu a na-adịghị mma na nkwado perisaiti [10] Ọnụ ọgụgụ dị ala nke pericytes gbara endothelium metụtara akpụ ahụ gburugburu ejikọtara ya na ọgba aghara nke akwara ọbara na leakiness.[11]

  1. ↑ 1.0 1.1 1.2 Dudley (2012-03-01). "Tumor Endothelial Cells" (in en). Cold Spring Harbor Perspectives in Medicine 2 (3): a006536. DOI:10.1101/cshperspect.a006536. ISSN 2157-1422. PMID 22393533.  Kpọpụta njehie: Invalid <ref> tag; name ":0" defined multiple times with different content
  2. ↑ 2.0 2.1 Hashizume (April 2000). "Openings between Defective Endothelial Cells Explain Tumor Vessel Leakiness". Am. J. Pathol. 156 (4): 1363–80. DOI:10.1016/S0002-9440(10)65006-7. PMID 10751361. 
  3. ↑ Lu (2007-02-16). "Gene Alterations Identified by Expression Profiling in Tumor-Associated Endothelial Cells from Invasive Ovarian Carcinoma". Cancer Research 67 (4): 1757–1768. DOI:10.1158/0008-5472.can-06-3700. PMID 17308118. 
  4. ↑ Hashizume (2017-04-21). "Openings between Defective Endothelial Cells Explain Tumor Vessel Leakiness". The American Journal of Pathology 156 (4): 1363–1380. DOI:10.1016/S0002-9440(10)65006-7. ISSN 0002-9440. PMID 10751361. 
  5. ↑ di Tomaso (2005-07-01). "Mosaic tumor vessels: cellular basis and ultrastructure of focal regions lacking endothelial cell markers". Cancer Research 65 (13): 5740–5749. DOI:10.1158/0008-5472.CAN-04-4552. ISSN 0008-5472. PMID 15994949. 
  6. ↑ Nagy (2007-01-01). "VEGF-A and the induction of pathological angiogenesis". Annual Review of Pathology 2: 251–275. DOI:10.1146/annurev.pathol.2.010506.134925. ISSN 1553-4006. PMID 18039100. 
  7. ↑ Padera (2004-02-19). "Pathology: cancer cells compress intratumour vessels". Nature 427 (6976): 695. DOI:10.1038/427695a. ISSN 1476-4687. PMID 14973470. 
  8. ↑ De Val (2009-02-01). "Transcriptional control of endothelial cell development". Developmental Cell 16 (2): 180–195. DOI:10.1016/j.devcel.2009.01.014. ISSN 1878-1551. PMID 19217421. 
  9. ↑ Hirschi (1996-10-01). "Pericytes in the microvasculature". Cardiovascular Research 32 (4): 687–698. DOI:10.1016/0008-6363(96)00063-6. ISSN 0008-6363. PMID 8915187. 
  10. ↑ Hellström (2001-04-30). "Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesis". The Journal of Cell Biology 153 (3): 543–553. DOI:10.1083/jcb.153.3.543. ISSN 0021-9525. PMID 11331305. 
  11. ↑ Baluk (2005-02-01). "Cellular abnormalities of blood vessels as targets in cancer". Current Opinion in Genetics & Development 15 (1): 102–111. DOI:10.1016/j.gde.2004.12.005. PMID 15661540. 
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