Ndepụta nhazi
Disposition index(DI) bu ihe eji agbako loop gain di na insulin glucose feedback control system. Akpowara ya dika meputa so na insulin sensitivity tinye kwuo insulin na adi na obara glucose level.[1][2] "Metabolically healthy" Ndị na-eguzogide insulin nwere ike ịnọgide na-enwe mmeghachi omume dị mma na glucose ọbara n'ihi eziokwu ahụ bụ na a na-ewepụta insulin dị elu ma ọ bụrụhaala na mkpụrụ ndụ beta nke pancreas nwere ike ịbawanye mmepụta insulin ha iji kwụọ ụgwọ maka iguzogide insulin. Mana ọnụọgụ nke mmụba na-arịwanye elu na plasma insulin metụtara mmụba nke plasma glucose (nchịkọta nhazi) na-enye ihe ka mma nke Ọrụ beta cell karịa mmeghachi omume plasma insulin na Ihe ịma aka glucose.[3] Mfu nke ọrụ nke mkpụrụ ndụ beta, na-ebelata ikike ha iji kwụọ ụgwọ maka iguzogide insulin, na-ebute akara ngosi dị ala.[1][1]
Mmetụta ahụike
[dezie | dezie ebe o si]A na-eji ndepụta nhazi eme ihe dị ka ihe atụ nke ọrụ beta cell na ikike nke ahụ iji kpochapụ ibu glucose. N'ihi ya, mbelata nke àgwà na-ebu amụma mgbanwe nke insulin na-eguzogide Ọrịa shuga Ụdị 2.[4]Nkọwa nke nhazi, mana ọ bụghị mgbochi insulin, nwere ike ịkọ ụdị ọrịa shuga nke 2 na ndị nwere ogo glucose dị mma n'ọbara, mana ndị na-enweghị akụkọ ezinụlọ (mgbasawanye mkpụrụ ndụ ihe nketa) maka ụdị ọrịa shuga 2.[5]
Enwere ike ịbawanye akara ngosi site na Mmega ahụ aerobic, mana naanị ruo n'ókè nke insulin na-emeziwanye.[6]
- ↑ 1.0 1.1 (2002) "Accurate assessment of beta-cell function: the hyperbolic correction". Diabetes 51 (Supp 1): S212–S220. DOI:10.2337/diabetes.51.2007.s212. PMID 11815482.
- ↑ Ferrannini (May 2004). "Beta cell function and its relation to insulin action in humans: a critical appraisal.". Diabetologia 47 (5): 943–56. DOI:10.1007/s00125-004-1381-z. PMID 15105990.
- ↑ Defronzo RA (2009). "Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus". Diabetes 58 (4): 773–795. DOI:10.2337/db09-9028. PMID 19336687.
- ↑ (2011) "Disposition index, glucose effectiveness, and conversion to type 2 diabetes: the Insulin Resistance Atherosclerosis Study (IRAS)". Diabetes Care 33 (9): 2098–2103. DOI:10.2337/dc10-0165. PMID 20805282.
- ↑ (2003) "Insulin resistance is a poor predictor of type 2 diabetes in individuals with no family history of disease". Proceedings of the National Academy of Sciences of the United States of America 100 (5): 2724–2729. DOI:10.1073/pnas.0438009100. PMID 12591951.
- ↑ (2013) "Pancreatic β-cell function is a stronger predictor of changes in glycemic control after an aerobic exercise intervention than insulin sensitivity". The Journal of Clinical Endocrinology and Metabolism 98 (10): 4176–4186. DOI:10.1210/jc.2013-2232. PMID 23966244.