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Ọrịa kansa akpịrị

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Templeeti:Infobox medical condition (new)Ọrịa kansa akpịrị bụ ọrịa kansa a na-adịghị ahụkebe, nke na-erughị mmadụ 2 na 100,000 kwa afọ na United States.[1] Ọ bụ ihe a na-ahụkarị na etiti na South America, etiti na ọwụwa anyanwụ Europe, Japan na ugwu India; ọ bụkwa ihe a na'etiti agbụrụ ụfọdụ dịka ndị India na ndị Hispanic.[2] Ọ bụrụ na a chọpụta ya n'oge, enwere ike ịgwọ ya site n'iwepụ eriri afọ, akụkụ nke imeju na lymph nodes metụtara ya. A na-ahụkarị ya mgbe mgbaàmà ndị dị ka ihe mgbu afọ, jaundice na ịgbọ agbọ, ọ gbasakwara n'akụkụ ndị ọzọ dị ka imeju.

Ọ bụ ọrịa kansa a na-adịghị ahụkebe nke a na-eche na ọ nwere njikọ na gallstones na-ewulite, nke nwekwara ike iduga na calcification nke gall bladder, ọnọdụ a maara dị ka porcelain gall bladder. Akpụkpọ ahụ nke eriri afọ bụkwa ihe a na-adịghị ahụkebe. Nnyocha ụfọdụ na-egosi na ndị nwere ụbụrụ ụbụrụ nwere nnukwu ihe ize ndụ nke ịrịa ọrịa kansa ụbụrụ, mana nyocha ndị ọzọ na-ajụ nke a. Atụmanya dị njọ maka mgbake ma ọ bụrụ na achọta ọrịa kansa mgbe mgbaàmà malitere, na ọnụọgụ ndụ afọ 5 nke fọrọ nke nta ka ọ bụrụ 3%.   [citation needed]

Ihe ịrịba ama na mgbaàmà

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  • Ihe mgbu na-adịgide adịgide n'elu afọ aka nri
  • Ọrịa na-agbari nri
  • Ịgbọ agbọ
  • Ike adịghị
  • Enweghị agụụ
  • Ibu ibu
  • Ọrịa na-acha odo odo na ịgbọ agbọ n'ihi mgbochi

Mgbaàmà ndị mbụ na-eṅomi ọzịza nke eriri afọ n'ihi nkume eriri afọ. Ka oge na-aga, mgbaàmà nwere ike ịbụ nke mgbochi afọ na afọ.   [citation needed]

N'ụzọ dị ịrịba ama, Iwu Courvoisier na-ekwu na n'ihu eriri afọ buru ibu nke na-enweghị mmasị ma na-esonyere obere jaundice na-enweghị ihe mgbu, o yighị ka ihe kpatara ya ga-abụ gallstones. Nke a na-egosi na ọ nwere ike ịbụ malignancy nke gall bladder ma ọ bụ pancreas, ọ gaghịkwa ekwe omume n'ihi gallstones n'ihi ọzịza na-adịghị ala ala nke jikọtara ya na gallstones na-eduga na obere, gall bladder na-adịghị agbatị. Otú ọ dị, nchọpụta mbụ nke Ludwig Georg Courvoisier, nke e bipụtara na Germany na 1890, edeghị aha ya na mbụ dị ka iwu, ọ dịghịkwa aha malignancy ma ọ bụ ihe mgbu (ịdị nro). A na-ekwukarị ihe ndị a n'ụzọ na-ezighi ezi ma ọ bụ na-agbagwoju anya n'akwụkwọ ahụike.[3]

Ihe ize ndụ

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  • Mmekọahụ - ihe dịka okpukpu abụọ karịa ụmụ nwanyị karịa ụmụ nwoke, na-abụkarị n'afọ iri nke asaa na nke asatọ
  • Ibubiga ibu ókè
  • Chorecystitis na cholelithiasis
  • Primary sclerosing cholangitis[4]
  • Ọrịa na-adịghị ala ala nke akpịrị; ndị na-ebu Salmonella typhi nwere ihe ize ndụ nke ọrịa kansa akpịrị okpukpu 3 ruo 200 karịa ndị na-abụghị ndị na-arịa ya na ihe ize ndụ ndụ nke ọrịa cancer [5]
  • E gosipụtara na ụdị nucleotide polymorphisms (SNPs) dị iche iche nwere njikọ na ọrịa kansa eriri afọ; Otú ọ dị, ọmụmụ ihe mkpụrụ ndụ ihe nketa dị ugbu a na GBC susceptibility ezughi ezu iji kwado njikọ ọ bụla [6]
  • Polyps nke eriri afọ[7]
  • Mgbidi eriri afọ calcified (porcelain gall bladder) [4][7]
  • Nsogbu ọmụmụ nke eriri afọ dị ka choledochal cyst [4][7]

Nnyocha

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Nnyocha mbụ agaghị ekwe omume n'ozuzu. A na-enyocha ndị nọ n'ihe ize ndụ dị elu, dị ka ụmụ nwanyị ma ọ bụ ụmụ amaala America nwere gallstones, nke ọma. Enwere ike iji ultrasound, CT scan, endoscopic ultrasound (MRI), na MR cholangio-pancreatography (MRCP) maka nchọpụta. A na-ahụ ọnụ ọgụgụ buru ibu nke ọrịa kansa eriri afọ na ndị ọrịa a na-enyocha maka cholelithiasis, ma ọ bụ mmepụta nke eriri afọ, nke a na-ahụkarị.[8] Nnyocha biopsy bụ naanị ụzọ doro anya iji mata ma uto tumorous ahụ ọ bụ ihe ọjọọ.[9]

  • Gallbladder adenocarcinoma lymphatic invasion histopathology
    Gallbladder adenocarcinoma lymphatic invasion histopathology
  • Incidentally discovered gallbladder cancer (adenocarcinoma) following a cholecystectomy.
    A chọpụtara na ọ bụ ọrịa kansa eriri afọ (adenocarcinoma) mgbe a na-aṅụ ọgwụCholecystectomy.
  • Gallbladder adenocarcinoma histopathology
    Ọrịa akpịrị adenocarcinomahistopathology

Nnyocha dị iche iche

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Xanthogranulomatous cholecystitis (XGC) bụ ụdị ọrịa akpịrị na-adịghị ahụkebe nke na-eṅomi ọrịa kansa akpịrị ọ bụ ezie na ọ bụghị ọrịa kansa.[10][11] Ọ bụ J.J. McCoy Jr., na ndị ọrụ ibe ya chọpụtara ya ma kọọ ya na akwụkwọ ahụike na 1976. [1] [12]

Ọgwụgwọ

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Ọ bụrụ na achọpụta ya n'oge na-adịghị agbasa, enwere ike ịgwọ ọrịa kansa eriri afọ site na ịwa ahụ. A na-akpọ ịwa ahụ maka ọrịa kansa eriri afọ radical Cholecystectomy ma ọ bụ extended cholecysteptomy.[13]Ọ na-agụnye iwepụ eriri afọ yana iwepụ ihe ndina imeju ya n'ụzọ zuru oke na anụ ahụ dị mma. A na-ewepụkwa lymph nodes dị nso. Mgbe ụfọdụ, a chọrọ iwepụ akụkụ dị ukwuu nke imeju a na-akpọ hepatectomy iji wepụ akpụ ahụ kpamkpam. Ọ dịkwa mkpa ka ewepụ eriri afọ ma ọ bụrụ na ọ metụtara ya.[7] Otú ọ dị, na ọrịa kansa gall bladder dị oke njọ, ọtụtụ ndị ọrịa ga-anwụ n'ime otu afọ nke ịwa ahụ. Ọ bụrụ na ịwa ahụ agaghị ekwe omume, stenting endoscopic ma ọ bụ percutaneous transhepatic biliary drainage (PTBD) nke osisi biliary nwere ike belata jaundice na stent n'ime afọ nwere ike belatara ịgbọ agbọ. A pụkwara iji ọgwụgwọ kemịkal na radiation mee ihe na ịwa ahụ. Ọ bụrụ na a chọpụta ọrịa kansa gall bladder mgbe cholecystectomy maka ọrịa nkume (ọrịa cancer mberede), a chọrọ ịwa ahụ ọzọ iji wepụ akụkụ nke imeju na lymph nodes n'ọtụtụ ọnọdụ. Mgbe emere ya n'oge o kwere mee, ndị ọrịa nwere ohere kachasị mma nke ịdị ndụ ogologo oge na ọbụna ọgwụgwọ.[14]

Ọrịa na-efe efe

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Ọtụtụ akpụ bụ adenocarcinomas, na obere pasent bụ squamous cell carcinomas.

  • Ọrịa kansa akpịrị bụ ihe a na-adịghị ahụkebe, na-emetụta ihe na-erughị mmadụ 5,000 na United States kwa afọ [15]
  • Ọrịa kansa akpịrị bụ ihe a na-ahụkarị na mba ndị dị na South America, Japan, na Israel; na Chile, ọrịa kansa akpịrị bụkwa ihe nke anọ na-akpata ọnwụ kansa.
  • Ọrịa kansa eriri afọ nke ise a na-ahụkarị
  • Ruo okpukpu ise karịa ụmụ nwanyị karịa ụmụ nwoke dabere na ọnụ ọgụgụ mmadụ (dịka 73% ụmụ nwanyị na China) [16]
  • Ọnụ ọgụgụ ndị na-arịa ọrịa kansa eriri afọ dị elu na Chile, na-esote na steeti Assam na India [17]

Ihe omuma

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Ọdịnihu ahụ ka dị njọ. Ọrịa kansa na-agbasa na imeju, eriri afọ, afọ, na duodenum.[18]

Nnyocha

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A na-enweta nghota ka mma banyere usoro ihe ọmụmụ nke ọrịa kansa biliary tract, gụnyere ọrịa cancer gallbladder, site na ọganihu na njirimara mkpụrụ ndụ ihe nketa profili genomic. [19] Nchọpụta a na-enye nghọta maka erughị eru dị na cell tumor iji mezie mmebi na DNA nke ha nke ọma. Ọkpụkpụ dị n'ihe dị ka 25% nke ndị ọrịa nwere ọrịa kansa biliary tract nwere ụdị ụfọdụ nke erughi nrụzi DNA. [19] Enwere ike iji ihe ọmụma nke ụkọ ndị dị otú ahụ mee ihe iji nwee ike ịbawanye nzaghachi na usoro ọgwụgwọ dị ugbu a dị ka chemotherapy, radiotherapy ma ọ bụ immunotherapy.

Ihe odide

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  1. ↑ Henley (2018-09-27). "CDC - Gallbladder Cancer Incidence and Death Rates" (in en-us). Cancer Epidemiology, Biomarkers & Prevention 24 (9): 1319–1326. DOI:10.1158/1055-9965.EPI-15-0199. PMID 26070529. Retrieved on 2018-12-10. 
  2. ↑ (2003) "Gallbladder cancer: an 'Indian' disease". Natl Med J India 16 (4): 209–13. PMID 14606770. 
  3. ↑ Fitzgerald (Apr 2009). "Courvoisier's gallbladder: law or sign?". World Journal of Surgery 33 (4): 886–91. DOI:10.1007/s00268-008-9908-y. ISSN 0364-2313. PMID 19190960. 
  4. ↑ Folseraas (February 2016). "Cancer Risk and Surveillance in Primary Sclerosing Cholangitis". Clinics in Liver Disease 20 (1): 79–98. DOI:10.1016/j.cld.2015.08.014. PMID 26593292. 
  5. ↑ Ferreccio (2012). "Salmonella typhi and Gallbladder Cancer", Bacteria and Cancer, 117–137. DOI:10.1007/978-94-007-2585-0_5. ISBN 978-94-007-2584-3. 
  6. ↑ Srivastava K, Srivastava A, Sharma KL, Mittal B. Candidate gene studies in gallbladder cancer: a systematic review and meta-analysis.
  7. ↑ 7.0 7.1 7.2 7.3 Gallbladder Cancer: Symptoms, Causes & Treatment | Dr. Nikhil Agrawal (en). Dr.Nikhil Agrawal. Retrieved on 2020-10-11.
  8. ↑ Duffy (2008-12-01). "Gallbladder cancer (GBC): 10-year experience at Memorial Sloan-Kettering Cancer Centre (MSKCC)". Journal of Surgical Oncology 98 (7): 485–489. DOI:10.1002/jso.21141. ISSN 1096-9098. PMID 18802958. 
  9. ↑ Tests for gallbladder cancer. Cancer Research UK. Archived from the original on 10 October 2011. Retrieved on 17 September 2012.
  10. ↑ (August 2009) "Xanthogranulomatous cholecystitis mimicking gallbladder carcinoma with a false-positive result on fluorodeoxyglucose PET". World J. Gastroenterol. 15 (29): 3691–3. DOI:10.3748/wjg.15.3691. PMID 19653352. 
  11. ↑ (2005) "Xanthogranulomatous cholecystitis: differentiation from associated gall bladder carcinoma". Trop Gastroenterol 26 (1): 31–3. PMID 15974235. 
  12. ↑ (March 1976) "Xanthogranulomatous cholecystitis. Report of two cases". J S C Med Assoc 72 (3): 78–9. PMID 1063276. 
  13. ↑ Cholecystectomy: Approaches and Technique. The Lecturio Medical Concept Library. Retrieved on 8 July 2021.
  14. ↑ Gallbladder Cancer Treatment (PDQ®)–Patient Version. National Cancer Institute (24 March 2004). Retrieved on 8 July 2021.
  15. ↑ Carriaga (1995-01-01). "Liver, gallbladder, extrahepatic bile ducts, and pancreas". Cancer 75 (1 Suppl): 171–190. DOI:<171::AID-CNCR2820751306>3.0.CO;2-2 10.1002/1097-0142(19950101)75:1+<171::AID-CNCR2820751306>3.0.CO;2-2. ISSN 0008-543X. PMID 8000995. 
  16. ↑ (December 2007) "Gallstones and the risk of biliary tract cancer: a population-based study in China". Br. J. Cancer 97 (11): 1577–82. DOI:10.1038/sj.bjc.6604047. PMID 18000509. 
  17. ↑ National Cancer Registry Programme (2013).
  18. ↑ Goetze (21 November 2015). "Gallbladder carcinoma: Prognostic factors and therapeutic options". World Journal of Gastroenterology 21 (43): 12211–12217. DOI:10.3748/wjg.v21.i43.12211. PMID 26604631. 
  19. ↑ 19.0 19.1 Lamarca A, Barriuso J, McNamara MG, Valle JW.

Njikọ mpụga

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Templeeti:Medical resourcesTempleeti:Digestive system neoplasia

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