Ethyl loflazepate
Ethyl loflazepate (nke a na-ere n'okpuru aha Meilax, Ronlax na Victan) bụ ọgwụ nke bụ benzodiazepine.[1][2][3] Ọ nwere ihe na-eme ka nchegbu kwụsị, ihe na-egbochi nkụchi, ihe na'ime ka ọ dị jụụ na ihe na-ehi ụra.[4] N'ọmụmụ anụmanụ, a chọpụtara nwere ihe mmụta sayensị na okpukpe mmalite nke narị afọ nke dị ka ndị na ọ nwere obere nsị, ọ bụ ezie na n'ime òké, ihe akaebe nke phospholipidosis nke akpa ume mere na mkpụrụ ndụ ụfụfụ na-etolite na iji ọgwụ dị elu eme ihe ogologo oge.[5] Ọkara ndụ ya bụ awa 51-103.[6] Usoro ọrụ ya yiri nke benzodiazepines ndị ọzọ. Ethyl loflazepate na-emepụta metabolite na-arụ ọrụ nke siri ike karịa nne na nna.[7] E mere Ethyl loflazepate ka ọ bụrụ ọgwụ maka descarboxyloflazepate, metabolite ya na-arụ ọrụ. Ọ bụ metabolite na-arụ ọrụ nke na-akpata ọtụtụ n'ime mmetụta ọgwụ karịa ethyl loflazepate.[8] Ndị isi metabolites nke ethyl loflazepate bụ descarbethoxyloflazepate, loflazepane na 3-hydroxydescarbethoxylflazepate.[9] Nchịkọta akụkọ ụra akpa dị ka onye isi oche nke metabolites na-arụ ọrụ nke ethyl loflazepate anaghị emetụta ndị nwere nkwarụ ma ọ bụrụ na anyị na ụdị nke ụwa na bụ nkwarụ.[10] Mgbaàmà nke oke ọgwụ ethyl loflazepate gụnyere ụra, ịma jijiji na ataxia. Hypotonia nwekwara ike ịpụta na ọrịa siri ike. Mgbaàmà ndị a na-apụta ugboro ugboro na nke siri ike n'ime ụmụaka.[11] Ọnwụ site na ọgwụgwọ mmezi ọgwụgwọ nke ethyl loflazepate e wepụtara maka izu 2 - 3 ka a kọrọ na ndị agadi 3 ndị ọrịa. Ihe kpatara ọnwụ ya bụ asphyxia n'ihi nsị benzodiazepine ndị na eme ka.[12] Nnukwu ọgwụ fluvoxamine na-egbochi ịda mbà n'obi nwere ike ime ka mmetụta ọjọọ nke ethyl loflazepate dịkwuo njọ.[13]
Ethyl loflazeplate na-ere ahịa na Mexico, n'okpuru aha azụmahịa Victan. A kwadoro ya maka ọnọdụ ndị a:[14][15]
- Nchegbu
- Nchegbu na-esote mmerụ ahụ
- Nchegbu metụtara nnukwu ihe mgbu na-emetụta akwara
- Nsogbu nchegbu zuru oke (GAD)
- Nsogbu na-emetụta uche
- Mwakpo egwu
- Ịgba aghara na-eme
Hụkwa
[dezie | dezie ebe o si]- Benzodiazepine
Ntụaka
[dezie | dezie ebe o si]- ↑ (October 1988) "New approach in bioavailability study of two formulations of ethyl loflazepate". Arzneimittel-Forschung 38 (10): 1486–1489. PMID 2904268.
- ↑ (1989) "Pharmacokinetic modeling of ethyl loflazepate (Victan) and its main active metabolites". Annals of Biomedical Engineering 17 (6): 633–646. DOI:10.1007/BF02367467. PMID 2574017.
- ↑ Benzodiazepine Names. non-benzodiazepines.org.uk. Archived from the original on 2008-12-08. Retrieved on 2009-04-05.
- ↑ (November 1983) "[Behavioral effects of ethyl loflazepate and its metabolites]". Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica 82 (5): 395–409. DOI:10.1254/fpj.82.395. PMID 6142848.
- ↑ (October 1981) "A toxicologic evaluation of ethyl fluclozepate (CM 6912)". International Journal of Clinical Pharmacology, Therapy, and Toxicology 19 (10): 453–472. PMID 6116677.
- ↑ (November 1980) "Quantitative analysis of CM 6912 (ethyl loflazepate) and its metabolites in plasma and urine by chemical ionization gas chromatography mass spectrometry. Application to pharmacokinetic studies in man". Biomedical Mass Spectrometry 7 (11–12): 565–571. DOI:10.1002/bms.1200071124. PMID 6112027.
- ↑ (April 1985) "Inhibitory effect on 3H-diazepam binding and potentiating action on GABA of ethyl loflazepate, a new minor tranquilizer". Japanese Journal of Pharmacology 37 (4): 373–379. DOI:10.1254/jjp.37.373. PMID 2861304.
- ↑ (1985) "Ethyl loflazepate: a prodrug from the benzodiazepine series designed to dissociate anxiolytic and sedative activities". Arzneimittel-Forschung 35 (10): 1573–1577. PMID 2866771.
- ↑ (1985) "Metabolism of ethyl loflazepate in the rat, the dog, the baboon and in man". Arzneimittel-Forschung 35 (7): 1061–1065. PMID 2864933.
- ↑ (1989) "Effect of renal failure on the pharmacokinetics of ethyl loflazepate (Victan) in man". Fundamental & Clinical Pharmacology 3 (1): 11–17. DOI:10.1111/j.1472-8206.1989.tb00025.x. PMID 2714728.
- ↑ (April 1992) "Acute poisonings with ethyle loflazepate, flunitrazepam, prazepam and triazolam in children". Veterinary and Human Toxicology 34 (2): 141–143. PMID 1354907.
- ↑ (March 2005) "Pharmacokinetics of the active metabolites of ethyl loflazepate in elderly patients who died of asphyxia associated with benzodiazepine-related toxicity". Journal of Analytical Toxicology 29 (2): 140–144. DOI:10.1093/jat/29.2.140. PMID 15902983.
- ↑ (December 2001) "[Effects of fluvoxamine on both the desired anxiolytic effect and the adverse motor incoordination and amnesia induced by benzodiazepines]". Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica 118 (6): 403–410. DOI:10.1254/fpj.118.403. PMID 11778459.
- ↑ Victan. saludzac.gob.mx/. Archived from the original on 2009-05-26. Retrieved on 2009-12-25.
- ↑ VICTAN. Farmacia Guerra. Archived from the original on 2013-12-31. Retrieved on 2009-12-25.