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Squamous-cell carcinoma

Shí Wikipedia, njikotá édémédé nke onyobulạ
Isi ihe ndị na-emetụta ọrịa nke carcinoma squamous-cell

Squamous-cell carcinoma (SCC), nke a makwaara dị ka carcinoma epidermoid, nwere ọtụtụ ụdị ọrịa cancer dị iche iche na-amalite na sel squamous.[1]Selụ ndị a na-etolite n'elu akpụkpọ ahụ, na mkpuchi nke akụkụ ahụ ndị nwere oghere dị n'ime ahụ, na mkpuchi nke iku ume na tract digestive.[1]

Ụdị ndị a na-ahụkarị gụnyere:

  • esophageal squamous-cell carcinoma: ụdị ọrịa kansa esophageel
  • carcinoma squamous-cell nke akpụkpọ ahụ: ụdị ọrịa kansa akpụkpọ ahụ
  • squamous-cell carcinoma nke akpa ume: ụdị ọrịa kansa akpa ume
  • squamous-cell carcinoma nke akụkụ ahụ nwanyị: ụdị ọrịa kansa akụkụ ahụ nwanyị
  • squamous-cell carcinoma nke thyroid: ụdị ọrịa kansa thyroid

N'agbanyeghị na-ekerịta aha "squamous-cell carcinoma", SCC nke saịtị ahụ dị iche iche nwere ike igosi ọdịiche dị na mgbaàmà ha gosipụtara, akụkọ ihe mere eme, prognosis, na nzaghachi ọgwụgwọ.

Site n'ebe ozu dị[dezie | dezie ebe o si]

A na-ejikọta nje virus nke mmadụ na SCCs nke oropharynx, akpa ume, mkpịsị aka, na mpaghara anogenital.[2][3]

Ọrịa kansa isi na olu[dezie | dezie ebe o si]

Nnukwu carcinoma squamous-cell nke ire dị ka a hụrụ na CT imaging

Ihe dị ka 90% nke ọrịa kansa isi na olu (ọrịa cancer nke ọnụ, oghere imi, nasopharynx, akpịrị na ihe ndị metụtara ya) bụ n'ihi SCC.[4]

Akpụkpọ ahụ[dezie | dezie ebe o si]

Carcinoma akpụkpọ ahụ squamous-cell bụ ọrịa kansa akpụkpọ ahụ nke abụọ a na-ahụkarị, na-akpata ihe karịrị 1 nde na United States kwa afọ.

Thyroid[dezie | dezie ebe o si]

Primary squamous-cell carcinoma nke thyroid na-egosi phenotype na-eme ihe ike nke na-akpata amụma ọjọọ maka ndị ọrịa.[5]

Esophagus[dezie | dezie ebe o si]

Ọrịa kansa esophageal nwere ike ịbụ n'ihi ma ọ bụ esophageel squamous-cell carcinoma (ESCC) ma ọ bụ adenocarcinoma (EAC). SCCs na-emekarị nso ọnụ, ebe adenocarcinomas na-eme nso afọ. Dysphagia (isi ike ilo, ihe siri ike karịa mmiri) na ihe mgbu ilo bụ ihe mgbaàmà mbụ a na-ahụkarị. Ọ bụrụ na ọrịa ahụ dị n'otu ebe, ịwa ahụ wepụ esophagus metụtara nwere ike inye ohere ọgwụgwọ. Ọ bụrụ na ọrịa ahụ agbasaala, a na-ejikarị ọgwụgwọ na radiotherapy eme ihe.[6]

Ụbụrụ[dezie | dezie ebe o si]

Foto nke carcinoma squamous-cell. Ọrịa ahụ dị n'aka ekpe, na-egbochi bronchus (akpa ume); karịa akpụ ahụ, bronchus na-afụ ụfụ ma nwee mucus.

Mgbe ejikọtara ya na akpa ume, ọ na-abụkarị ọrịa kansa nnukwu mkpụrụ ndụ dị n'etiti (ọ bụghị obere mkpụrụ ndụ kansa akpa ume). Ọ na-enwekarị ọrịa paraneoplastic na-akpata mmepụta ectopic nke protein metụtara parathyroid hormone, na-akpatara hypercalcemia, mana ọrịa paraneplastic na-ejikọkarị ya na obere ọrịa kansa akpa ume. Ọ bụ n'ihi ịṅụ sịga.[7]

Ubi ahụ́[dezie | dezie ebe o si]

Human papillomavirus (HPV), nke bụ isi HPV 16 na 18, na-emetụta ya nke ukwuu na mmepe nke SCC nke penis. Carcinomas atọ na-ejikọta na SCCs nke penis: [citation needed]

  1. Ọrịa Bowen na-egosi dị ka leukoplakia na shaft. Ihe dị ka otu ụzọ n'ụzọ atọ nke ikpe na-aga n'ihu na SCC.
  2. Erythroplasia nke Queyrat, ụdị ọrịa Bowen, gosipụtara dị ka erythroplakia na glans.
  3. Bowenoid papulosis, nke yiri ọrịa Bowen, na-egosi dị ka papules na-acha ọbara ọbara.[8]

Prostate[dezie | dezie ebe o si]

Mgbe ejikọtara ya na prostate, carcinoma squamous-cell na-eme ihe ike n'okike. O siri ike ịchọpụta ebe ọ bụ na a hụghị mmụba na ọkwa antigen nke prostate, nke pụtara na a na-achọpụta ọrịa kansa mgbe ọ dị elu. [citation needed]

Mkpịsị aka nwanyị na akpa nwa[dezie | dezie ebe o si]

Carcinoma squamous-cell nke akụkụ ahụ nwanyị na-agbasa nwayọọ nwayọọ ma na-anọkarị nso n'akụkụ akụkụ ahụ nwanyị, mana ọ nwere ike ịgbasa na akpa ume na imeju. Nke a bụ ụdị ọrịa kansa a na-ahụkarị n'ahụ nwanyị.[9]

Bladder[dezie | dezie ebe o si]

Ọtụtụ ọrịa kansa ụkwara bụ mkpụrụ ndụ na-agafe agafe, mana ọrịa kansa ụgbụ metụtara schistosomiasis na-abụkarị SCC. [citation needed]

Nnyocha[dezie | dezie ebe o si]

Biopsy nke carcinoma squamous-cell dị iche iche nke ọnụ. Ụdị mkpụrụ ndụ carcinoma squamous-cell buru ibu na ọtụtụ eosinophilic cytoplasm na nnukwu, mgbe mgbe vesicular, nuclei.[10] Haematoxylin & eosin stain
Cytopathology nke squamous-cell carcinoma, ụdị keratinizing, nwere njirimara ndị a na-ahụkarị.[11] Ọkpụkpụ papa.
Cytopathology nke squamous-cell carcinoma, ụdị na-abụghị keratinizing, nwere njirimara.[12] Ọkpụkpụ papa. N'agbanyeghị nke ahụ, nchọpụta ndị a n'ozuzu ha abụghị ihe doro anya karịa maka keratinizing squamous-cell carcinoma, a pụkwara ịhụ ọtụtụ n'ime ha na ọrịa kansa ndị ọzọ dịka adenocarcinoma (nke, Otú ọ dị, na-enwekarị chromatin dị mma).[13]

Akụkọ ahụike, nyocha ahụike na ihe oyiyi ahụike nwere ike ịnye echiche carcinoma squamous-cell, mana biopsy maka histopathology n'ozuzu ya na-egosi nchọpụta ahụ. TP63 staining bụ isi ihe na-egosi histological maka squamous-cell carcinoma. Na mgbakwunye, TP63 bụ ihe dị mkpa maka transcription iji guzobe njirimara nke mkpụrụ ndụ squamous.[14]

Nchịkọta[dezie | dezie ebe o si]

Enwere ike iwere kansa dị ka nnukwu ezinụlọ dị iche iche nke ọrịa ọjọọ, yana squamous-cell carcinomas mejupụtara otu n'ime nnukwu subset.[15][16][17] A na-eche na mmerụ ahụ SCC niile na-amalite site na nkewa ugboro ugboro, nke a na-achịkwaghị achịkwa nke mkpụrụ ndụ cancer stem nke agbụrụ epithelial ma ọ bụ njirimara. [citation needed] SCCs na-esite na mkpụrụ ndụ squamous, nke bụ mkpụrụ ndụ dị larịị nke dị n'ọtụtụ ebe nke ahụ. Ụfọdụ n'ime ha bụ keratinocytes. Nchịkọta nke mkpụrụ ndụ kansa ndị a na-akpata microscopic focus nke mkpụrụ ndụ na-adịghị mma nke, ọ dịkarịa ala na mbido, na-ejide n'ime anụ ahụ a kapịrị ọnụ nke mkpụrụ ndụ nna ya bi. A na-akpọ ọnọdụ a squamous-cell carcinoma in situ, a na-achọpụta ya mgbe akpụ ahụ abanyebeghị n'ime ala ma ọ bụ ihe ndị ọzọ na-eme ka ọ ghara ịbanye <i id="mwwQ">n'ime</i> anụ ahụ ndị dị n'akụkụ. Ozugbo mmerụ ahụ toro ma gaa n'ihu ruo n'ókè ebe ọ gbawara, banye, ma banye n'ime ihe ndị dị n'akụkụ ya, a na-akpọ ya "invasive" squamous-cell carcinoma. Ozugbo carcinoma na-awakpo, ọ nwere ike ịgbasa na akụkụ ndị ọzọ ma mee ka ọ gbasaa, ma ọ bụ "ọkpụkpụ nke abụọ". [citation needed]

Akpụkpọ ahụ e si nweta ya[dezie | dezie ebe o si]

Usoro International Classification of Diseases for Oncology (ICD-O) depụtara ọtụtụ ụdị ọdịdị na ụdị dị iche iche nke malignant squamous-cell neoplasms, gụnyere:[18]

  • Papillary thyroid carcinoma (koodu 8050/3)
  • carcinoma na-acha uhie uhie (koodu 8051/3)
  • Papillary squamous-cell carcinoma (koodu 8052/3)
  • squamous-cell carcinoma (koodu 8070/3)
  • nnukwu mkpụrụ ndụ keratinizing squamous-cell carcinoma (koodu 8071/3)
  • carcinoma squamous-cell na-enweghị keratinizing (koodu 8072/3)
  • obere mkpụrụ ndụ keratinizing squamous-cell carcinoma (koodu 8073/3)
  • spindle-cell squamous-cell carcinoma (koodu 8074/3) A makwaara ya dị ka spindle- cell carcinoma, ọ bụkwa ụdị nke mkpụrụ ndụ atypical dị ka spinder.[19][20]
  • adenoid/pseudoglandular squamous-cell carcinoma (koodu 8075/3)
  • intraepidermal squamous-cell carcinoma (koodu 8081/3)
  • lymphoepithelial carcinoma (koodu 8082/3).

A na-amata ụdị SCC ndị ọzọ n'okpuru usoro ndị ọzọ, dị ka keratoacanthoma.

Ụdị ndị ọzọ nke histopathologic[dezie | dezie ebe o si]

  • Erythroplasia nke Queyrat
  • Ọnyá Marjolin bụ ụdị SCC nke na-esite na ọnyá na-adịghị agwọ ọrịa ma ọ bụ ọnyá ọkụ. Otú ọ dị, ihe akaebe ndị ọzọ na-adịbeghị anya na-egosi na ọdịiche dị n'etiti mkpụrụ ndụ ihe nketa dị n'agbata SCC na ọnyá Marjolin, nke a na-eleda anya na mbụ.[21]

Otu usoro nke ịkewapụta carcinomas squamous-cell bụ site na ọdịdị ha n'okpuru microscope. Ụdị ndị ọzọ nwere ike ịgụnye:

  • adenoid squamous-cell carcinoma (nke a makwaara dị ka pseudoglandular squamous'cell carcinomas) bụ nke a na-eji usoro microscopic tubular na keratinocyte acantholysis mara.[20]
  • basaloid squamous-cell carcinoma bụ nke a na-ahụkarị maka isi ire.[20]
  • carcinoma squamous-cell doro anya (nke a makwaara dị ka carcinoma nke akpụkpọ ahụ) bụ nke keratinocytes na-egosi na ọ dị ọcha n'ihi ọzịza hydropic.[20]
  • signet ring-cell squamous-cell carcinoma (nke a na-asụgharị mgbe ụfọdụ dị ka signet ring - cell squamous - cell carcinoma) bụ ụdị histological nke a na-akọwa site na mgbanaka concentric nke nwere keratin na nnukwu vacuoles kwekọrọ na endoplasmic reticulum.[20] Vacuoles ndị a na-eto ruo n'ókè nke na ha na-ebugharị nucleus nke mkpụrụ ndụ gaa na membrane nke mkpụrụ ndụ, na-enye mkpụrụ ndụ ọdịdị dị iche iche na "mgbaaka akara" mgbe a na-ele ya anya n'okpuru microscope.

Mgbochi[dezie | dezie ebe o si]

YouNnyocha achọtawo ihe akaebe maka njikọ dị n'etiti nri na ọrịa kansa akpụkpọ ahụ, gụnyere SCC. Iri nri mmiri ara ehi nwere abụba dị elu na-eme ka ihe ize ndụ nke SCC tumor dịkwuo elu n'etiti ndị nwere ọrịa kansa akpụkpọ ahụ n'oge gara aga. Akwụkwọ nri na-acha akwụkwọ ndụ akwụkwọ ndụ nwere ike inye aka gbochie mmepe nke SCC na-esote na ọtụtụ ọmụmụ chọpụtara na akwụkwọ nri na mkpụrụ osisi na-enweghị isi na-echebe nke ukwuu megide ihe ize ndụ SCC.[22][23] N'aka nke ọzọ, iri mmiri ara ehi zuru oke, yogọt, na cheese nwere ike ịbawanye ihe ize ndụ SCC na ndị nwere ike ibute ya.[24] Na mgbakwunye, usoro nri anụ na abụba nwere ike ịbawanye ihe ize ndụ nke SCC na ndị na-enweghị akụkọ ihe mere eme nke SCC, mana njikọ ahụ bụ ihe a ma ama na ndị nwere akụkọ ihe mere anya nke ọrịa kansa akpụkpọ ahụ.[25] Ịṅụ sịga na usoro nri nke a na-ahụkarị site na nnukwu biya na mmanya na-aba n'anya na-emekwa ka ihe ize ndụ nke SCC dịkwuo ukwuu.[26][22]

Ihe odide[dezie | dezie ebe o si]

  1. 1.0 1.1 NCI Dictionary of Cancer Terms. National Cancer Institute (2011-02-02). Retrieved on 9 November 2016.
  2. (June 2009) "Correlation of HPV-16/18 infection of human papillomavirus with lung squamous cell carcinomas in Western China". Oncology Reports 21 (6): 1627–32. DOI:10.3892/or_00000397. PMID 19424646. 
  3. Recurrent Squamous Cell Carcinoma In Situ of the Finger. Retrieved on 2010-09-22.
  4. Types of head and neck cancer - Understanding - Macmillan Cancer Support. Retrieved on 15 March 2017.
  5. (January 2011) "Squamous cell carcinoma of the thyroid gland: primary or secondary disease?". The Journal of Laryngology and Otology 125 (1): 3–9. DOI:10.1017/S0022215110002070. PMID 20950510. 
  6. Esophageal Cancer. The Lecturio Medical Concept Library (26 October 2020). Retrieved on 6 August 2021.
  7. Pooler (2010). Porth pathophysiology: concepts of altered health states, 1st Canadian, Philadelphia, PA: Wolters Kluwer Health/Lippincott Williams & Wilkins, 660. ISBN 978-1-60547-781-7. 
  8. Robbins (2007). Robbins Basic Pathology, 8th, Philadelphia: Saunders/Elsevier, 688. ISBN 978-1-4160-2973-1. 
  9. Squamous-cell Carcinoma of the Vagina. www.dynamed.com. Archived from the original on 2018-02-20. Retrieved on 2018-02-20.
  10. Dr Nicholas Turnbull, A/Prof Patrick Emanual (2014-05-03). Squamous cell carcinoma pathology. DermNetz.
  11. - Image annotated by Mikael Häggström

    - Reference for entries: Gulisa Turashvili, M.D., Ph.D.. Cervix - Squamous cell carcinoma and variants. Pathology Outlines. Last author update: 24 September 2020. Last staff update: 4 April 2022.

    - Source image from National Cancer Institute (Public Domain)
  12. - Image annotated by Mikael Häggström

    - Reference for entries: Gulisa Turashvili, M.D., Ph.D.. Cervix - Squamous cell carcinoma and variants. Pathology Outlines. Last author update: 24 September 2020. Last staff update: 4 April 2022.

    - Source image by Ravi Mehrotra, Anurag Gupta, Mamta Singh and Rahela Ibrahim (Creative Commons Attribution 2.0 Generic license.)
  13. Authors: Caroline I.M. Underwood, M.D., Alexis Musick, B.S., Carolyn Glass, M.D., Ph.D.. Adenocarcinoma overview. Pathology Outlines. Last staff update: 19 July 2022
  14. (April 2020) "Maintaining protein stability of ∆Np63 via USP28 is required by squamous cancer cells". EMBO Molecular Medicine 12 (4): e11101. DOI:10.15252/emmm.201911101. PMID 32128997. 
  15. (November 2004) "Tumor taxonomy for the developmental lineage classification of neoplasms". BMC Cancer 4 (1): 88. DOI:10.1186/1471-2407-4-88. PMID 15571625. 
  16. (March 2004) "Tumor classification: molecular analysis meets Aristotle". BMC Cancer 4 (1): 10. DOI:10.1186/1471-2407-4-10. PMID 15113444. 
  17. (2004) in Travis: Pathology and Genetics of Tumours of the Lung, Pleura, Thymus and Heart, World Health Organization Classification of Tumours. Lyon: IARC Press. ISBN 978-92-832-2418-1. Retrieved on 27 March 2010. 
  18. Van Holten (1990). in Muir: International Classification of Diseases for Oncology: ICD-0, 2nd, Geneva, Switzerland: World Health Organization. ISBN 9789241544146. 
  19. Rapini (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 978-1-4160-2999-1. 
  20. 20.0 20.1 20.2 20.3 20.4 (2003) in Fitzpatrick: Fitzpatrick's dermatology in general medicine, 6th, New York, NY: McGraw-Hill. ISBN 978-0-07-138076-8. 
  21. (January 2017) "Transcriptional Analysis Reveals Evidence of Chronically Impeded ECM Turnover and Epithelium-to-Mesenchyme Transition in Scar Tissue Giving Rise to Marjolin's Ulcer". Journal of Burn Care & Research 38 (1): e14–e22. DOI:10.1097/BCR.0000000000000432. PMID 27679957. 
  22. 22.0 22.1 (October 2003) "Food groups and risk of squamous cell carcinoma of the oesophagus: a case-control study in Uruguay". British Journal of Cancer 89 (7): 1209–14. DOI:10.1038/sj.bjc.6601239. PMID 14520448. 
  23. (July 2009) "Food intake and the occurrence of squamous cell carcinoma in different sections of the esophagus in Taiwanese men". Nutrition 25 (7–8): 753–61. DOI:10.1016/j.nut.2009.02.002. PMID 19394796. 
  24. (October 2006) "Food intake and risk of squamous cell carcinoma of the skin in a community: the Nambour skin cancer cohort study". International Journal of Cancer 119 (8): 1953–60. DOI:10.1002/ijc.22061. PMID 16721782. 
  25. (May 2007) "Dietary pattern in association with squamous cell carcinoma of the skin: a prospective study". The American Journal of Clinical Nutrition 85 (5): 1401–8. DOI:10.1093/ajcn/85.5.1401. PMID 17490979. 
  26. (2006) "Dietary patterns and risk of squamous-cell carcinoma and adenocarcinoma of the esophagus and adenocarcinoma of the gastric cardia: a population-based case-control study in Sweden". Nutrition and Cancer 54 (2): 171–8. DOI:10.1207/s15327914nc5402_3. PMID 16898861.